Role of immunotherapy in triple-negative breast cancer

TE Keenan, SM Tolaney - Journal of the National Comprehensive Cancer …, 2020 - jnccn.org
Immune checkpoint inhibitors (ICIs) have led to durable clinical remissions in many
metastatic cancers. However, the single-agent efficacy of ICIs in breast cancer is low …

The emerging role of immune checkpoint inhibitors in the treatment of triple-negative breast cancer

S Singh, A Numan, B Maddiboyina, S Arora, Y Riadi… - Drug discovery today, 2021 - Elsevier
Highlights•TNBCs is one of the most heterogenous form of breast cancer appear to have
elevated numbers of immune cells infiltration.•Using immune checkpoint inhibitors (ICIs) …

[HTML][HTML] Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of breast cancer

LA Emens, S Adams, A Cimino-Mathews… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Breast cancer has historically been a disease for which immunotherapy was largely
unavailable. Recently, the use of immune checkpoint inhibitors (ICIs) in combination with …

Immunotherapy for triple-negative breast cancer: combination strategies to improve outcome

L Li, F Zhang, Z Liu, Z Fan - Cancers, 2023 - mdpi.com
Simple Summary For decades, countless efforts have been devoted to developing targeted
drugs to improve the prognosis of triple-negative breast cancer (TNBC). Among the novel …

Immunotherapy in triple negative breast cancer: beyond checkpoint inhibitors

Y Abdou, A Goudarzi, JX Yu, S Upadhaya… - NPJ Breast …, 2022 - nature.com
The development of immunotherapy agents has revolutionized the field of oncology. The
only FDA-approved immunotherapeutic approach in breast cancer consists of immune …

Immune-based combinations for metastatic triple negative breast cancer in clinical trials: current knowledge and therapeutic prospects

A Rizzo, AD Ricci, L Lanotte, L Lombardi… - Expert opinion on …, 2022 - Taylor & Francis
Introduction Immune checkpoint inhibitor (ICI) monotherapy appears to be effective in a
small cohort of patients with metastatic triple negative breast cancer (mTNBC). This supports …

Immune checkpoint inhibitors in triple negative breast cancer treatment: promising future prospects

R Thomas, G Al-Khadairi, J Decock - Frontiers in oncology, 2021 - frontiersin.org
Immunotherapy has emerged as the fifth pillar of cancer treatment alongside surgery,
radiotherapy, chemotherapy, and targeted therapy. Immune checkpoint inhibitors are the …

Role of immunotherapy in breast cancer

SL Jacob, LA Huppert, HS Rugo - JCO Oncology Practice, 2023 - ascopubs.org
The advent of immunotherapy, particularly immune checkpoint inhibitors (ICIs), has
revolutionized the treatment of solid tumor malignancies. In breast cancer, the most robust …

Immunotherapy toxicity: Identification and management

O Gumusay, J Callan, HS Rugo - Breast Cancer Research and Treatment, 2022 - Springer
The widespread adoption of immunotherapy has revolutionized the treatment of various
cancer types, including metastatic triple-negative breast cancer (TNBC), which has long …

Progress and prospect of immunotherapy for triple-negative breast cancer

C Luo, P Wang, S He, J Zhu, Y Shi, J Wang - Frontiers in Oncology, 2022 - frontiersin.org
Breast cancer is the most commonly diagnosed cancer (estimated 2.3 million new cases in
2020) and the leading cause of cancer death (estimated 685,000 deaths in 2020) in women …