Immunomodulatory therapeutic proteins in COVID‐19: current clinical development and clinical pharmacology considerations

P Ji, J Chen, A Golding, NP Nikolov… - The Journal of …, 2020 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic caused by infection with
SARS‐CoV‐2 has led to more than 600 000 deaths worldwide. Patients with severe disease …

Immunomodulatory agents as potential therapeutic or preventive strategies for COVID-19

R Gaziano, ES Pistoia, E Campione… - European Review for …, 2021 - art.torvergata.it
Abstract Currently, the COVID-19 pandemic, caused by the novel SARS-CoV-2 coronavirus,
represents the greatest global health threat. Most people infected by the virus present mild to …

Immune dysfunction in COVID-19 and judicious use of antirheumatic drugs for thetreatment of hyperinflammation

A Tufan, M Matucci-Cerinic - Turkish Journal of Medical …, 2021 - journals.tubitak.gov.tr
In the Wuhan province of China, almost two years ago, in December 2019, the novel
Coronavirus 2019 has caused a severe involvement of the lower respiratory tract leading to …

A 21st century evil: immunopathology and new therapies of COVID-19

TF Silva, F Tomiotto-Pellissier, RA Sanfelice… - Frontiers in …, 2020 - frontiersin.org
Coronavirus Disease 2019 (COVID-19) has been classified as a global threat, affecting
millions of people and killing thousands. It is caused by the SARS-CoV-2 virus, which …

Pharmaco-immunomodulatory therapy in COVID-19

JG Rizk, K Kalantar-Zadeh, MR Mehra, CJ Lavie… - Drugs, 2020 - Springer
The severe acute respiratory syndrome coronavirus 2 associated coronavirus disease 2019
(COVID-19) illness is a syndrome of viral replication in concert with a host inflammatory …

Coronavirus disease-2019: A review on the disease exacerbation via cytokine storm and concurrent management

H Sunkara, SMR Dewan - International immunopharmacology, 2021 - Elsevier
Abstract Setting up treatment strategies is the highest concern today to reduce the fatality of
COVID-19. Due to a very new kind of virus attack, no specific treatment has been discovered …

[HTML][HTML] Calming the inflammatory storm in severe COVID-19 infections: Role of biologics-A narrative review

D Banji, SS Alqahtani, OJF Banji… - Saudi Pharmaceutical …, 2021 - Elsevier
The risk of Coronavirus infection continues, and the fear of resurgence indicates the lack of a
successful therapeutic strategy. In severe COVID-19 infection, many immune cells and their …

Cytokine storm in COVID-19: immunopathogenesis and therapy

C Zanza, T Romenskaya, AC Manetti, F Franceschi… - Medicina, 2022 - mdpi.com
A cytokine storm is a hyperinflammatory state secondary to the excessive production of
cytokines by a deregulated immune system. It manifests clinically as an influenza-like …

Review on therapeutic targets for COVID-19: insights from cytokine storm

ML de Mélo Silva Júnior, LMA de Souza… - Postgraduate …, 2021 - academic.oup.com
Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been
caused the greatest pandemic of our century. Many of the deaths related to it are due to a …

Macrophage responses associated with COVID-19: A pharmacological perspective

GW Booz, R Altara, AH Eid, Z Wehbe, S Fares… - European Journal of …, 2020 - Elsevier
COVID-19 has caused worldwide death and economic destruction. The pandemic is the
result of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has …