The 22q11. 2 deletion is the strongest known genetic risk factor for schizophrenia. Research
has implicated microRNA-mediated dysregulation in 22q11. 2 deletion syndrome (22q11 …

The role of microRNAs (miRNAs) in the etiology of schizophrenia is increasingly recognized.
Microdeletions at chromosome 22q11. 2 are recurrent structural variants that impart a high …

Individuals with 22q11. 2 microdeletions have cognitive and behavioral impairments and the
highest known genetic risk for developing schizophrenia. One gene disrupted by the 22q11 …

In humans, the most common genomic disorder is a hemizygous deletion of a 1.5–3 Mb
region of chromosome 22q11. 2. The resultant 22q11. 2 deletion syndrome (22q11. 2DS) …

The 22q11. 2 deletion is associated with> 20-fold increased risk for schizophrenia. The
presence of gene DGCR8 in the 22q11. 2 deletion region has suggested microRNA …

Background Neuronal phenotypes associated with hemizygosity of individual genes within
the 22q11. 2 deletion syndrome locus hold potential towards understanding the …

Background: Schizophrenia is a complex neuropsychiatric disorder of unclear etiology. The
strongest known genetic risk factor is the 22q11. 2 microdeletion. Research has yet to …

Abnormalities in microRNA (miRNA)-mediated gene regulation have been observed in a
variety of human diseases, especially in cancer. Here, we provide an account of newly …

Summary 22q11. 2 microdeletions result in specific cognitive deficits and schizophrenia.
Analysis of Df (16) A+/− mice, which model this microdeletion, revealed abnormalities in the …

Summary Individuals with 22q11. 2 deletion syndrome (22q11DS) are at high risk of
developing psychiatric diseases such as schizophrenia. Individuals with 22q11DS and …