[HTML][HTML] Human diversity of killer cell immunoglobulin-like receptors and disease

R Rajalingam - The Korean journal of hematology, 2011 - synapse.koreamed.org
Natural Killer (NK) cells are the third population of lymphocyte in the mononuclear cell
compartment that triggers first-line of defense against viral infection and tumor …

Killer cell immunoglobulin‐like receptors on NK cells: the how, where and why

CM Gardiner - International journal of immunogenetics, 2008 - Wiley Online Library
Natural killer (NK) cells have killer cell immunoglobulin‐like receptors (KIR) that recognize
and interact with HLA class I antigen. The KIRs are a multigene family and its members are …

HLA reduces killer cell Ig-like receptor expression level and frequency in a humanized mouse model

J van Bergen, A Thompson, M van Pel… - The Journal of …, 2013 - journals.aai.org
NK cells use NK cell receptors to be able to recognize and eliminate infected, transformed,
and allogeneic cells. Human NK cells are prevented from killing autologous healthy cells by …

The Yin and Yang of HLA and KIR in human disease

S Kulkarni, MP Martin, M Carrington - Seminars in immunology, 2008 - Elsevier
Killer cell immunoglobulin-like receptors (KIR) are expressed on natural killer (NK) cells and
subsets of T cells. The KIR genes are polymorphic and the KIR gene complex is polygenic …

Structure/function of human killer cell immunoglobulin‐like receptors: lessons from polymorphisms, evolution, crystal structures and mutations

KS Campbell, AK Purdy - Immunology, 2011 - Wiley Online Library
Stimulation or tolerance of natural killer (NK) cells is achieved through a cross‐talk of signals
derived from cell surface activating and inhibitory receptors. Killer cell immunoglobulin‐like …

Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression …

S Becker, T Tonn, T Füssel, M Uhrberg, M Bogdanow… - Human immunology, 2003 - Elsevier
Natural killer (NK) cell-mediated cytolysis is stimulated and downregulated through the
interaction of distinct human leukocyte antigen (HLA) class I molecules on target cells with …

Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop

MK Misra, DG Augusto, GM Martin, N Nemat-Gorgani… - Human immunology, 2018 - Elsevier
The goals of the KIR component of the 17th International HLA and Immunogenetics
Workshop (IHIW) were to encourage and educate researchers to begin analyzing KIR at …

Killer immunoglobulin-like receptors

L Moretta, A Moretta - Current opinion in immunology, 2004 - Elsevier
Killer Ig-like receptors (KIRs) are surface inhibitory receptors specific for allelic forms of
human leukocyte antigen (HLA) class I molecules, which are expressed by natural killer …

Can we make a better match or mismatch with KIR genotyping?

RS Mehta, K Rezvani - Hematology 2014, the American Society …, 2016 - ashpublications.org
Natural killer (NK) cell function is regulated by a fine balance between numerous activating
and inhibitory receptors, of which killer-cell immunoglobulin-like receptors (KIRs) are among …

KIR and KIR ligand polymorphism: a new area for clinical applications?

M Falco, L Moretta, A Moretta, C Bottino - Tissue Antigens, 2013 - Wiley Online Library
Killer immunoglobulin‐like receptors (KIRs) play an essential role in the regulation of natural
killer (NK) activity, allowing NK cells to sense and respond to human leukocyte antigen …