The high comorbidity rates of posttraumatic stress disorder and chronic pain have been
widely reported, but the underlying mechanisms remain unclear. Emerging evidence …

Stress has been shown to enhance pain sensitivity resulting in stress-induced hyperalgesia.
However, the underlying mechanisms have yet to be elucidated. Using single-prolonged …

A growing body of evidence from both clinical and animal studies indicates that chronic
neuropathic pain is associated with comorbid affective disorders. Spinal cord microglial …

Clinical studies indicate that psychosocial stress contributes to adverse chronic pain
outcomes in patients, but it is unclear how this is initiated or amplified by stress. Repeated …

Lesions of peripheral nerves lead to pain, hyperalgesia, and psychological comorbidities.
However, the relationship between mood disorders and neuropathic pain is unclear, as well …

Some recent evidence suggests that microglia activation and inflammatory cytokine
production in the hippocampus are associated with the development of pain behavior …

The dentate gyrus of the hippocampus is the primary location of adult neurogenesis, which
is affected by a variety of external and internal factors, including activity of surrounding glial …

We have proposed that neuropathic pain engages emotional learning, suggesting the
involvement of the hippocampus. Because cytokines in the periphery contribute to induction …

The high prevalence of chronic pain in posttraumatic stress disorder (PTSD) individuals has
been widely reported by clinical studies, which emphasized an urgent need to uncover the …

Neuronal plasticity along the pathway for sensory transmission including the spinal cord and
cortex plays an important role in chronic pain, including inflammatory and neuropathic pain …