Exosomes as a drug delivery system in cancer therapy: potential and challenges

G Kibria, EK Ramos, Y Wan, DR Gius… - Molecular …, 2018 - ACS Publications
Exosomes play a pivotal role in mediating intercellular communications and package
delivery. They have recently been discovered to serve as diagnostic biomarkers as well as a …

Diagnostic and therapeutic potential of exosomes in cancer: the beginning of a new tale?

H Mirzaei, A Sahebkar, MR Jaafari… - Journal of cellular …, 2017 - Wiley Online Library
Exosomes have emerged as one of the main players in intercellular communication. These
small nano‐sized particles have many roles in various physiological pathways in normal …

Exosome-mimetic nanoplatforms for targeted cancer drug delivery

AJ Vázquez-Ríos, Á Molina-Crespo, BL Bouzo… - Journal of …, 2019 - Springer
Background Lack of effective tumor-specific delivery systems remains an unmet clinical
challenge for successful translation of innovative therapies, such as, therapeutic …

Role of exosomes and exosomal microRNAs in cancer

N Dilsiz - Future science OA, 2020 - Taylor & Francis
A growing body of evidence indicates that exosomes play a critical role in the cell–cell
communication process. Exosomes are biological nanoparticles with an average diameter of …

Recent progress in exosome research: isolation, characterization and clinical applications

X Wang, J Xia, L Yang, J Dai, L He - Cancer Gene Therapy, 2023 - nature.com
Exosomes, a kind of nano-vesicles released by various cell types, carry a variety of “cargos”
including proteins, RNAs, DNAs and lipids. There is substantial evidence that exosomes are …

Milk exosomes: A biogenic nanocarrier for small molecules and macromolecules to combat cancer

R Kandimalla, F Aqil, N Tyagi… - American Journal of …, 2021 - Wiley Online Library
Exosomes are unique biogenic nanocarriers of endocytic origin that are generated from
most of the cells and found in biofluids like milk, plasma, saliva, and urine. Bovine milk …

[HTML][HTML] Exosome as drug delivery system: Current advancements

V Sharma, CD Mukhopadhyay - Extracellular Vesicle, 2024 - Elsevier
Exosomes are nanovesicles released from cells due to pathophysiological events. These
nanoparticles are resistant to metabolic destruction and can transcend the blood-brain …

Exploring the potential of engineered exosomes as delivery systems for tumor-suppressor microRNA replacement therapy in ovarian cancer

M Kobayashi, K Sawada, M Miyamoto… - Biochemical and …, 2020 - Elsevier
MicroRNA (miRNA) plays a pivotal role in cancer biology. Therefore, tumor suppressor (TS)
miRNAs are an attractive target for cancer therapy. However, clinical trials have failed due to …

A novel peptide-equipped exosomes platform for delivery of antisense oligonucleotides

H Xu, C Liao, S Liang, BC Ye - ACS Applied Materials & Interfaces, 2021 - ACS Publications
Exosomes are natural delivery vehicles because of their original feature such as low
immunogenicity, excellent biocompatibility, and migration capability. Engineering exosomes …

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

J Wahlgren, TDL Karlson, M Brisslert… - Nucleic acids …, 2012 - academic.oup.com
Despite the promise of RNA interference (RNAi) and its potential, eg for use in cancer
therapy, several technical obstacles must first be overcome. The major hurdle of RNAi …