The development of sufficient vascular networks is crucial for the successful fabrication of
tissue constructs for regenerative medicine, as vascularization is essential to perform the …

Vascularization in bone tissues is essential for the distribution of nutrients and oxygen, as
well as the removal of waste products. Fabrication of tissue-engineered bone constructs with …

Abstract 3D bioprinting has begun to show great promise in advancing the development of
functional tissue/organ replacements. However, to realize the true potential of 3D bioprinted …

Vascularization is a fundamental prerequisite for large bone construct development and
remains one of the main challenges of bone tissue engineering. Our current study presents …

Vascularization has a pivotal role in engineering successful tissue constructs. However, it
remains a major hurdle of bone tissue engineering, especially in clinical applications for the …

A functional vascular supply is a key component of any large-scale tissue, providing support
for the metabolic needs of tissue-remodeling cells. Although well-studied strategies exist to …

Fabricating 3D large‐scale bone tissue constructs with functional vasculature has been a
particular challenge in engineering tissues suitable for repairing large bone defects. To …

In the past three decades, tissue engineering has made great progress in fabricating various
artificial tissues with simple structures, achieving partially functional restoration in …

Large bone defects remain an unsolved clinical challenge because of the lack of effective
vascularization in newly formed bone tissue. 3D bioprinting is a fabrication technology with …

The crosstalk between osteoblasts and endothelial cells is critical for bone vascularization
and regeneration. Here, we used a coaxial 3D bioprinting method to directly print an osteon …