Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19)

B Diao, C Wang, Y Tan, X Chen, Y Liu, L Ning… - Frontiers in …, 2020 - frontiersin.org
Background: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human health …

Decreased T cell populations contribute to the increased severity of COVID-19

R Liu, Y Wang, J Li, H Han, Z Xia, F Liu, K Wu… - Clinica Chimica …, 2020 - Elsevier
Background We observe changes of the main lymphocyte subsets (CD16+ CD56, CD19,
CD3, CD4, and CD8) in COVID-19-infected patients and explore whether the changes are …

Reduction and exhausted features of T lymphocytes under serological changes, and prognostic factors in COVID-19 progression

A Mahmoodpoor, M Hosseini, S Soltani-Zangbar… - Molecular …, 2021 - Elsevier
Abstract Aims Coronavirus disease 2019 (COVID-19) is a novel viral infection threatening
worldwide health as currently there exists no effective treatment strategy and vaccination …

Suppressed T cell-mediated immunity in patients with COVID-19: a clinical retrospective study in Wuhan, China

XU Bo, C Fan, A Wang, Y Zou, Y Yu, HE Cong, W Xia… - Journal of Infection, 2020 - Elsevier
Importance An ongoing outbreak of COVID-19 has exhibited significant threats around the
world. We found a significant decrease of T lymphocyte subsets and an increase of …

COVID-19 pneumonia: CD8+ T and NK cells are decreased in number but compensatory increased in cytotoxic potential

Y Jiang, X Wei, J Guan, S Qin, Z Wang, H Lu, J Qian… - Clinical …, 2020 - Elsevier
Abstract Background Coronavirus disease 2019 (COVID-19) is posing a huge threat to
human health worldwide. We aim to investigate the immune status of CD8+ T and NK cells …

Reappearance of effector T cells is associated with recovery from COVID-19

I Odak, J Barros-Martins, B Bošnjak, K Stahl, S David… - …, 2020 - thelancet.com
Background Elucidating the role of T cell responses in COVID-19 is of utmost importance to
understand the clearance of SARS-CoV-2 infection. Methods 30 hospitalized COVID-19 …

[HTML][HTML] Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity

CK Kang, GC Han, M Kim, G Kim, HM Shin… - International Journal of …, 2020 - Elsevier
Objectives We hypothesized that immune response may contribute to progression of
coronavirus disease-19 (COVID-19) at the second week of illness. Therefore, we compared …

Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China

C Qin, L Zhou, Z Hu, S Zhang, S Yang… - Clinical infectious …, 2020 - academic.oup.com
Abstract Background In December 2019, coronavirus 2019 (COVID-19) emerged in Wuhan
and rapidly spread throughout China. Methods Demographic and clinical data of all …

Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients

HY Zheng, M Zhang, CX Yang, N Zhang… - Cellular & molecular …, 2020 - nature.com
The novel contagious primary atypical pneumonia epidemic, which broke out in Wuhan,
China, in December 2019, is now formally called Coronavirus Disease 2019 (COVID-19) …

Epidemiological and clinical features of COVID-19 patients with and without pneumonia in Beijing, China

P Yang, Y Ding, Z Xu, R Pu, P Li, J Yan, J Liu, F Meng… - Medrxiv, 2020 - medrxiv.org
Abstract Background SARS-CoV-2-caused coronavirus disease (COVID-19) is posing a
large casualty. The features of COVID-19 patients with and without pneumonia, SARS-CoV …