Despite the pronounced neurological deficits associated with mental retardation and autism,
the degree to which neocortical circuit function is altered remains unknown. Here, we study …

Despite the pronounced neurological deficits associated with mental retardation and autism,
it is unknown if altered neocortical circuit function occurs in these prevalent disorders. Here …

Subtle alterations in how cortical network dynamics are modulated by different behavioral
states could disrupt normal brain function and underlie symptoms of neuropsychiatric …

Fragile X syndrome (FXS) is the most common heritable cause of intellectual disability and
single-gene cause of autism spectrum disorder. The Fmr1 null mouse models much of the …

Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by severe
cognitive impairments, sensory hypersensitivity, and comorbidities with autism and epilepsy …

Background Cortical hyperexcitability due to abnormal fast-spiking inhibitory interneuron
function has been documented in fmr1 KO mice, a mouse model of the fragile X syndrome …

Fragile X syndrome (FXS) is the most prevalent inherited cause of autism and is
accompanied by behavioral and sensory deficits. Errors in the wiring of the brain during …

Fragile X syndrome (FXS) is the most common single gene (FMR1) disorder affecting
cognitive and behavioral function in humans. This syndrome is characterized by a cluster of …

Key points Cortico‐hippocampal feed‐forward circuits formed by the temporoammonic (TA)
pathway exhibit a marked increase in excitation/inhibition ratio and abnormal spike …

Identification of comparable biomarkers in humans and validated animal models will
facilitate pre-clinical to clinical therapeutic pipelines to treat neurodevelopmental disorders …