Blood leukocyte DNA methylation predicts risk of future myocardial infarction and coronary heart disease: a longitudinal study of 11 461 participants from population …

G Agha, MM Mendelson, CK Ward-Caviness… - Circulation, 2019 - Am Heart Assoc
Background: DNA methylation is implicated in coronary heart disease (CHD), but current
evidence is based on small, cross-sectional studies. We examined blood DNA methylation …

Blood DNA methylation and incident coronary heart disease: evidence from the strong heart study

A Navas-Acien, A Domingo-Relloso, P Subedi… - JAMA …, 2021 - jamanetwork.com
Importance American Indian communities experience a high burden of coronary heart
disease (CHD). Strategies are needed to identify individuals at risk and implement …

The role of DNA methylation in cardiovascular risk and disease: methodological aspects, study design, and data analysis for epidemiological studies

J Zhong, G Agha, AA Baccarelli - Circulation research, 2016 - Am Heart Assoc
Epidemiological studies have demonstrated that genetic, environmental, behavioral, and
clinical factors contribute to cardiovascular disease development. How these risk factors …

[HTML][HTML] DNA methylation and cardiovascular disease in humans: a systematic review and database of known CpG methylation sites

M Krolevets, V Cate, JH Prochaska, A Schulz… - Clinical …, 2023 - Springer
Background Cardiovascular disease (CVD) is the leading cause of death worldwide and
considered one of the most environmentally driven diseases. The role of DNA methylation in …

[HTML][HTML] Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

S Guarrera, G Fiorito, NC Onland-Moret, A Russo… - Clinical …, 2015 - Springer
Background DNA methylation profiles are responsive to environmental stimuli and metabolic
shifts. This makes DNA methylation a potential biomarker of environmental-related and …

Genome-wide analysis of DNA methylation and acute coronary syndrome

J Li, X Zhu, K Yu, H Jiang, Y Zhang, S Deng… - Circulation …, 2017 - Am Heart Assoc
Rationale: Acute coronary syndrome (ACS) is a leading cause of death worldwide. Immune
functions play a vital role in ACS development; however, whether epigenetic modulation …

[HTML][HTML] DNA methylation signatures of incident coronary heart disease: findings from epigenome-wide association studies

Y Xia, A Brewer, JT Bell - Clinical Epigenetics, 2021 - Springer
Coronary heart disease (CHD) is a type of cardiovascular disease (CVD) that affects the
coronary arteries, which provide oxygenated blood to the heart. It is a major cause of …

Ischemic heart disease and stroke in relation to blood DNA methylation

A Baccarelli, R Wright, V Bollati, A Litonjua… - …, 2010 - journals.lww.com
Background: Epigenetic features such as DNA hypomethylation have been associated with
conditions related to cardiovascular risk. We evaluated whether lower blood DNA …

Association between DNA methylation and coronary heart disease or other atherosclerotic events: a systematic review

A Fernández-Sanlés, S Sayols-Baixeras, I Subirana… - Atherosclerosis, 2017 - Elsevier
Background and aims The aim of this study was to perform a systematic review of the
association between DNA methylation and coronary heart disease (CHD) or related …

Association of cardiovascular health through young adulthood with genome-wide DNA methylation patterns in midlife: the CARDIA study

Y Zheng, BT Joyce, SJ Hwang, J Ma, L Liu, NB Allen… - Circulation, 2022 - Am Heart Assoc
Background: Cardiovascular health (CVH) from young adulthood is strongly associated with
an individual's future risk of cardiovascular disease (CVD) and total mortality. Defining …