Lactic acid bacteria—promising vaccine vectors: possibilities, limitations, doubts

K Szatraj, AK Szczepankowska… - Journal of Applied …, 2017 - academic.oup.com
Gram‐positive, nonpathogenic lactic acid bacteria (LAB) are considered to be promising
candidates for the development of novel, safe production and delivery systems of …

Novel Strategies for Efficient Production and Delivery of Live Biotherapeutics and Biotechnological Uses of Lactococcus lactis: The Lactic Acid Bacterium Model

LM Tavares, LSCL De Jesus, TF Da Silva… - … in Bioengineering and …, 2020 - frontiersin.org
Lactic acid bacteria (LAB) are traditionally used in fermentation and food preservation
processes and are recognized as safe for consumption. Recently, they have attracted …

Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update

JG LeBlanc, C Aubry, NG Cortes-Perez… - FEMS microbiology …, 2013 - academic.oup.com
Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms naturally
present in many foods and those have proved to be effective mucosal delivery vectors …

Use of native lactococci as vehicles for delivery of DNA into mammalian epithelial cells

VD Guimarães, S Innocentin, F Lefèvre… - Applied and …, 2006 - Am Soc Microbiol
The use of the food-grade bacterium Lactococcus lactis as a DNA delivery vehicle at the
mucosal level is an attractive DNA vaccination strategy. Previous experiments showed that …

Lactobacillus Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens

JS LeCureux, GA Dean - Msphere, 2018 - Am Soc Microbiol
Lactic acid bacteria (LAB) have been utilized since the 1990s for therapeutic heterologous
gene expression. The ability of LAB to elicit an immune response against expressed foreign …

Cell surface display system for Lactococcus lactis: a novel development for oral vaccine

AR Raha, NRS Varma, K Yusoff, E Ross… - Applied microbiology and …, 2005 - Springer
The food-grade Lactococcus lactis is a potential vector to be used as a live vehicle for the
delivery of heterologous proteins for vaccine and pharmaceutical purposes. We constructed …

[HTML][HTML] Internalin-expressing Lactococcus lactis is able to invade small intestine of guinea pigs and deliver DNA into mammalian epithelial cells

VD Guimarães, JE Gabriel, F Lefèvre, D Cabanes… - Microbes and …, 2005 - Elsevier
The use of the food-grade bacterium Lactococcus lactis as antigen delivery vehicle at the
mucosal level is an attractive vaccination strategy intensively explored during the last …

Recombinant lactic acid bacteria as promising vectors for mucosal vaccination

N Qiao, G Du, X Zhong, X Sun - Exploration, 2021 - Wiley Online Library
Lactic acid bacteria (LAB), a diverse family of gram‐positive bacteria, has been proven
effective in delivering varieties of therapeutic and prophylactic molecules such as antigens …

Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria

JM Wells, A Mercenier - Nature Reviews Microbiology, 2008 - nature.com
Studies of lactic acid bacteria (LAB) as delivery vehicles have focused mainly on the
development of mucosal vaccines, with much effort being devoted to the generation of …

In vivo transfer of plasmid from food-grade transiting lactococci to murine epithelial cells

JM Chatel, L Pothelune, S Ah-Leung, G Corthier… - Gene therapy, 2008 - nature.com
We recently demonstrated that noninvasive food-grade Lactococcus lactis (L. lactis) can
deliver eukaryotic expression plasmid in mammalian cells in vitro. Here, we evaluated, in …