Cytokines may be important mediators of β-cell damage in early insulin-dependent diabetes
mellitus. In order to further characterize the mechanism (s) of action of cytokines on insulin …

Cytokines have been implicated in pancreatic β-cell destruction leading to type 1 diabetes.
In vitro, a combination of γ-interferon (IFN-γ) and interleukin-1 (IL-1) stimulate inducible nitric …

Cytokines may participate in islet destruction during the development of type 1 diabetes.
Expression of inducible nitric oxide synthase (iNOS) and subsequent NO formation induced …

Cytokines produced by immune system cells infiltrating pancreatic islets are candidate
mediators of islet beta-cell destruction in insulin-dependent diabetes mellitus. In this study …

Insulin-dependent diabetes mellitus (IDDM) is a disease that results from autoimmune
destruction of the insulin-producing β-cells in the pancreatic islets of Langerhans. The …

Nitric oxide has been implicated as one possible mediator of interleukin-1β (IL-1)-induced
inhibition of insulin secretion and islet cell damage. The aim of this study was to define the …

Cytokines have been proposed as inducers of beta-cell damage in human insulin-
dependent diabetes mellitus via the generation of nitric oxide (NO). This concept is mostly …

Abstract Interferon‐γ (IFN‐γ) is known to exert deleterious effects on pancreatic β‐cells and
is implicated in the development of type 1 (autoimmune) diabetes mellitus. In this study, we …

Inflammatory cytokines and nitric oxide (NO) are candidate mediators of pancreatic islet beta-
cell destruction in insulin-dependent diabetes mellitus. In this study, we used a …

Nicotinamide (NA) prevents macrophage-and interleukin-1 (IL-1)-mediated β-cell damage in
vitro as well as diabetes development in animal models of insulin-dependent diabetes …