Matrix abnormalities in pulmonary fibrosis

C Upagupta, C Shimbori, R Alsilmi… - European Respiratory …, 2018 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive disease, marked by
excessive scarring, which leads to increased tissue stiffness, loss in lung function and …

[HTML][HTML] Epithelial-mesenchymal transition contributes to pulmonary fibrosis via aberrant epithelial/fibroblastic cross-talk

C Hill, MG Jones, DE Davies… - Journal of lung health and …, 2019 - ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is the prototypic progressive fibrotic interstitial lung
disease. Median survival is only 3 years, and treatment options are limited. IPF is thought to …

The pathogenesis of idiopathic pulmonary fibrosis

WR Coward, G Saini, G Jenkins - Therapeutic advances in …, 2010 - journals.sagepub.com
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an appalling
prognosis. The failure of anti-inflammatory therapies coupled with the observation that …

Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets

JC Hewlett, JA Kropski, TS Blackwell - Matrix Biology, 2018 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic disease of the lung that is marked by
progressive decline in pulmonary function and ultimately respiratory failure. Genetic and …

The extracellular matrix and mechanotransduction in pulmonary fibrosis

Z Deng, MW Fear, YS Choi, FM Wood… - The international journal …, 2020 - Elsevier
Pulmonary fibrosis is characterised by excessive scarring in the lung which leads to
compromised lung function, serious breathing problems and in some diseases, death. It …

[HTML][HTML] Idiopathic pulmonary fibrosis: immunohistochemical analysis provides fresh insights into lung tissue remodelling with implications for novel prognostic …

NJ Lomas, KL Watts, KM Akram… - … journal of clinical and …, 2012 - ncbi.nlm.nih.gov
Aim This study explored the cellular and biological interrelationships involved in Idiopathic
Pulmonary Fibrosis (IPF) lung tissue remodelling using immunohistochemical analysis …

Epithelial–mesenchymal transition in the pathogenesis of idiopathic pulmonary fibrosis

F Salton, MC Volpe, M Confalonieri - Medicina, 2019 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a serious disease of the lung, which leads to extensive
parenchymal scarring and death from respiratory failure. The most accepted hypothesis for …

Role of integrin-mediated TGFβ activation in the pathogenesis of pulmonary fibrosis

A Goodwin, G Jenkins - Biochemical Society Transactions, 2009 - portlandpress.com
IPF (idiopathic pulmonary fibrosis) is a chronic progressive disease of unknown aetiology
without effective treatment. IPF is characterized by excessive collagen deposition within the …

Tissue remodelling in pulmonary fibrosis

L Knudsen, C Ruppert, M Ochs - Cell and tissue research, 2017 - Springer
Many lung diseases result in fibrotic remodelling. Fibrotic lung disorders can be divided into
diseases with known and unknown aetiology. Among those with unknown aetiology …

Idiopathic pulmonary fibrosis: from epithelial injury to biomarkers-insights from the bench side

M Kolb, K Borensztajn, B Crestani, M Kolb - Respiration, 2014 - karger.com
Idiopathic pulmonary fibrosis (IPF) is the most frequent fibrotic diffuse parenchymal lung
disease. Its prognosis is devastating:> 50% of the patients die within 3 years after diagnosis …