Omeprazole is a class referred to as proton pump inhibitor; it acts to regulate acid production
in the stomach and is used to treat various acid-related gastrointestinal disorders. In the …

We present a new simple and reliable HPLC method for measuring omeprazole and its two
main metabolites in plasma. This can be used for studying CYP2C19 and CYP3A4 genetic …

Studies investigating the relationship between CYP2C19 genotype and the stereoselective
metabolism of omeprazole have not been reported. In the present study, we developed a …

A direct injection high-performance liquid chromatographic (HPLC) method, with column-
switching, for the determination of omeprazole enantiomers in human plasma is described …

A simple and sensitive column-switching high-performance liquid chromatographic method
was developed for the simultaneous determination of omeprazole and its two main …

Omeprazole is a benzimidazole compound that acts as a proton-pump inhibitor. Because
the metabolism of omeprazole is mainly catalyzed by cytochrome P-450 (CYP) 3A4 and …

A simple HPLC-DAD method using a reverse phase column and isocratic elution for the
simultaneous determination of omeprazole (OME), 5-hydroxyomeprazole (HOME) and …

Abstract Background Polymorphism of CYP2C19 gene is one of the important factors in
pharmacokinetics of CYP2C19 substrates. Omeprazole is a proton pump inhibitor which is …

A fully automated liquid chromatography-tandem mass spectrometry (LC–MS/MS) method
was developed for the determination of omeprazole in human plasma. Utilization of 96-well …

A practical and selective HPLC method for the separation and quantification of omeprazole
enantiomers in human plasma is presented. C18 solid phase extraction (SPE) cartridges …