Data-driven multi-scale mathematical modeling of SARS-CoV-2 infection reveals heterogeneity among COVID-19 patients

S Wang, M Hao, Z Pan, J Lei, X Zou - PLoS Computational …, 2021 - journals.plos.org
Patients with coronavirus disease 2019 (COVID-19) often exhibit diverse disease
progressions associated with various infectious ability, symptoms, and clinical treatments. To …

Dynamic heterogeneity in COVID-19: Insights from a mathematical model

C Voutouri, CC Hardin, V Naranbhai, MR Nikmaneshi… - Plos one, 2024 - journals.plos.org
Critical illness, such as severe COVID-19, is heterogenous in presentation and treatment
response. However, it remains possible that clinical course may be influenced by dynamic …

Computational simulations to dissect the cell immune response dynamics for severe and critical cases of SARS-CoV-2 infection

R Blanco-Rodriguez, X Du… - Computer methods and …, 2021 - Elsevier
Background: COVID-19 is a global pandemic leading to high death tolls worldwide day by
day. Clinical evidence suggests that COVID-19 patients can be classified as non-severe …

In silico dynamics of COVID-19 phenotypes for optimizing clinical management

C Voutouri, MR Nikmaneshi… - Proceedings of the …, 2021 - National Acad Sciences
Understanding the underlying mechanisms of COVID-19 progression and the impact of
various pharmaceutical interventions is crucial for the clinical management of the disease …

Modeling recapitulates the heterogeneous outcomes of SARS-CoV-2 infection and quantifies the differences in the innate immune and CD8 T-cell responses between …

B Chatterjee, H Singh Sandhu, NM Dixit - PLoS pathogens, 2022 - journals.plos.org
SARS-CoV-2 infection results in highly heterogeneous outcomes, from cure without
symptoms to acute respiratory distress and death. Empirical evidence points to the …

Mechanistic modeling of the SARS-CoV-2 and immune system interplay unravels design principles for diverse clinicopathological outcomes

S Sahoo, K Hari, S Jhunjhunwala, MK Jolly - BioRxiv, 2020 - biorxiv.org
The disease caused by SARS-CoV-2 is a global pandemic that threatens to bring long-term
changes worldwide. Approximately 80% of infected patients are asymptomatic or have mild …

Dynamical modelling of viral infection and cooperative immune protection in COVID-19 patients

Z Zhou, D Li, Z Zhao, S Shi, J Wu, J Li… - PLOS Computational …, 2023 - journals.plos.org
Once challenged by the SARS-CoV-2 virus, the human host immune system triggers a
dynamic process against infection. We constructed a mathematical model to describe host …

The good, the bad and the ugly: A mathematical model investigates the differing outcomes among CoVID-19 patients

S Sahoo, S Jhunjhunwala, MK Jolly - Journal of the Indian Institute of …, 2020 - Springer
The disease caused by SARS-CoV-2—CoVID-19—is a global pandemic that has brought
severe changes worldwide. Approximately 80% of the infected patients are largely …

From Infection to Immunity: Understanding the Response to SARS-CoV2 Through In-Silico Modeling

F Castiglione, D Deb, AP Srivastava, P Liò… - Frontiers in …, 2021 - frontiersin.org
Background Immune system conditions of the patient is a key factor in COVID-19 infection
survival. A growing number of studies have focused on immunological determinants to …

A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS …

KS Kim, K Ejima, S Iwanami, Y Fujita, H Ohashi… - PLoS …, 2021 - journals.plos.org
The scientific community is focused on developing antiviral therapies to mitigate the impacts
of the ongoing novel coronavirus disease 2019 (COVID-19) outbreak. This will be facilitated …