Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important
self-protection mechanisms against stimuli and infections. Hosts can defend against …

Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to
induce strong inflammatory responses that defend the host against microbe infection …

Gasdermin E (GSDME) is a member of the gasdermin protein family, which mediates
programmed cell death including apoptosis and pyroptosis. Recently, it was suggested that …

Recent findings have revealed that the protein gasdermin D (GSDMD) plays key roles in cell
pyroptosis. GSDMD binds lipids and forms pore structures to induce pyroptosis upon …

Gasdermins (GSDMs) are a class of pore-forming proteins related to pyroptosis, a
programmed cell death pathway that is induced by a range of inflammatory stimuli. Small …

Gasdermin D (GSDMD) serves as a key executor to trigger pyroptosis and is emerging as an
attractive checkpoint in host defense, inflammatory, autoimmune diseases, and many other …

Pyroptosis is an inflammatory form of programmed cell death that plays important roles in
immune protection against infections and in inflammatory disorders. Gasdermin D (GSDMD) …

Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in
macrophages to protect hosts from intracellular bacteria. Here, we reveal that GSDMD …

Pyroptosis, a lytic form of programmed cell death, both stimulates effective immune
responses and causes tissue damage. Gasdermin (GSDM) proteins are a family of pore …

Gasdermin B (GSDMB) has been reported to be associated with immune diseases in
humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of …