Since 10 years ago, when the seven hallmarks of cancer were first defined by Hanahan and
Weinberg, after decades of molecular, cellular and clinical investigations, new systems …

Cancer is a complex and heterogeneous disease, not only at a genetic and biochemical
level, but also at a tissue, organism, and population level. Multiple data streams, from …

In order to understand how a cancer cell is functionally different from a normal cell it is
necessary to assess the complex network of pathways involving gene regulation, signaling …

Cancer phenotypes, referred to as hallmarks of cancer, are acquired by dysregulation of
biochemical networks, in addition to genetic and epigenetic alterations. For the last decade …

Cancer Systems Biology is now accepted and recognized as a promising field both in
biological and clinical research. It relies on a rigorous formalization of regulation networks …

Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …

Rather than a strictly formalized methodological framework, we here describe systems
biology as a flexible approach in which the modelling strategy used depends on a trade-off …

The twenty-fi rst century has witnessed rapid advancement in computational technologies
that are increasingly being applied in cancer research. Thanks to availability of these high …

Background: Frequently occurring in cancer are the aberrant alterations of regulatory onco-
metabolites, various oncogenes/epigenetic stochasticity, and suppressor genes, as well as …

'The definitive property of individuality at the organismal level lies in the effective
suppression of the differential propagation of subparts as a necessary strategy for …