Immunological and inflammatory profiles in mild and severe cases of COVID-19

JW Song, C Zhang, X Fan, FP Meng, Z Xu, P Xia… - Nature …, 2020 - nature.com
Abstract COVID-19 is associated with 5.1% mortality. Although the virological,
epidemiological, clinical, and management outcome features of COVID-19 patients have …

Exuberant elevation of IP-10, MCP-3 and IL-1ra during SARS-CoV-2 infection is associated with disease severity and fatal outcome

Y Yang, C Shen, J Li, J Yuan, M Yang, F Wang, G Li… - MedRxiv, 2020 - medrxiv.org
The outbreak of Coronavirus Disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, December 2019 …

Interleukin-17A (IL-17A), a key molecule of innate and adaptive immunity, and its potential involvement in COVID-19-related thrombotic and vascular mechanisms

F Raucci, AA Mansour, GM Casillo, A Saviano… - Autoimmunity …, 2020 - Elsevier
Discussion Taking all these various pieces of evidence (albeit minimal), we would like to
hypothesize that in COVID-19 patients, IL-17A could potentially promote a pro-thrombotic …

[HTML][HTML] Transcriptional changes in CD16+ monocytes may contribute to the pathogenesis of COVID-19

V Chilunda, P Martinez-Aguado, LC Xia… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 pandemic has caused more than three million deaths globally. The severity
of the disease is characterized, in part, by a dysregulated immune response. CD16+ …

Dynamic blood single-cell immune responses in patients with COVID-19

L Huang, Y Shi, B Gong, L Jiang, Z Zhang… - Signal transduction and …, 2021 - nature.com
Abstract The 2019 coronavirus disease (COVID-19) outbreak caused by the SARS-CoV-2
virus is an ongoing global health emergency. However, the virus' pathogenesis remains …

[PDF][PDF] Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

M Koutsakos, LC Rowntree, L Hensen, BY Chua… - Cell Reports …, 2021 - cell.com
SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …

[HTML][HTML] Monocytes and Macrophages in COVID-19

R Knoll, JL Schultze, J Schulte-Schrepping - Frontiers in immunology, 2021 - frontiersin.org
COVID-19 is a contagious viral disease caused by SARS-CoV-2 that led to an ongoing
pandemic with massive global health and socioeconomic consequences. The disease is …

Unique immunological profile in patients with COVID-19

S Varchetta, D Mele, B Oliviero, S Mantovani… - Cellular & molecular …, 2021 - nature.com
The relationship between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
and host immunity is poorly understood. We performed an extensive analysis of immune …

How COVID-19 induces cytokine storm with high mortality

S Hojyo, M Uchida, K Tanaka, R Hasebe… - Inflammation and …, 2020 - Springer
The newly emerging coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, but …

COVID-19-induced ARDS is associated with decreased frequency of activated memory/effector T cells expressing CD11a++

M Anft, K Paniskaki, A Blazquez-Navarro, A Doevelaar… - Molecular Therapy, 2020 - cell.com
Preventing the progression to acute respiratory distress syndrome (ARDS) in COVID-19 is
an unsolved challenge. The involvement of T cell immunity in this exacerbation remains …