Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed
susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we …
susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we …
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease
(AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 …
(AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 …
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by
previous studies; however, a large portion of the genetic risk for this disease remains …
previous studies; however, a large portion of the genetic risk for this disease remains …
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
K Bettens, N Brouwers, S Engelborghs… - Molecular …, 2012 - Springer
Background We have followed-up on the recent genome-wide association (GWA) of the
clusterin gene (CLU) with increased risk for Alzheimer disease (AD), by performing an …
clusterin gene (CLU) with increased risk for Alzheimer disease (AD), by performing an …
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes
Objectives: To determine whether genotypes at CLU, PICALM, and CR1 confer risk for
Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced …
Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced …
Alzheimer's disease: one disorder, too many genes?
The research of Alzheimer's disease (AD) genetics has been extremely prolific over the past
decade, and currently more than 10 genes are reported to show either positive or negative …
decade, and currently more than 10 genes are reported to show either positive or negative …
Results of a high-resolution genome screen of 437 Alzheimer's disease families
D Blacker, L Bertram, AJ Saunders… - Human molecular …, 2003 - academic.oup.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder of late life with
complex inheritance. Mutations in three known genes lead to the rare early-onset autosomal …
complex inheritance. Mutations in three known genes lead to the rare early-onset autosomal …
Genetics of Alzheimer's disease: new evidences for an old hypothesis?
JC Lambert, P Amouyel - Current opinion in genetics & development, 2011 - Elsevier
Alzheimer's disease (AD) is the prime cause of dementia and presents a strong genetic
predisposition (60–80% of the attributable risk). In addition to APOE, a major recognized …
predisposition (60–80% of the attributable risk). In addition to APOE, a major recognized …
New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. To date four
genes have been established to either cause early-onset autosomal-dominant AD (APP …
genes have been established to either cause early-onset autosomal-dominant AD (APP …