Genetic variation underlying hypothalamic pituitary adrenal (HPA) axis overactivity in
healthy controls (HCs) and patients with severe forms of major depression has not been well …

The hypothalamic–pituitary–adrenal (HPA) axis has been implicated in the pathophysiology
of a variety of mood and cognitive disorders. Neuroendocrine studies have demonstrated …

Abstract Objectives. This Anna Monika Award Lecture updates the role of the hypothalamic–
pituitary–adrenal (HPA) axis in the pathogenesis and treatment of psychotic major …

Objective: Genetic variation within the hypothalamic-pituitary-adrenal (HPA) axis has been
linked to risk for depression and antidepressant response. However, these associations …

Objective. To summarize current concepts on neuroendocrine and genetic principles
underlying stress-related depression and to discuss the challenges of personalized …

Background Major depressive disorder (MDD) is a serious, and common psychiatric
disorder worldwide. By the year 2020, MDD will be the second cause of disability in the …

BACKGROUND: Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been
observed in major depression. Normalization of HPA axis has been suggested to play a role …

The dysregulation of the activity of the hypothalamic-pituitary-adrenocortical (HPA) axis
system is one of the major neuroendocrine abnormalities in major depression (MD). Many …

BACKGROUND: Depressive patients often have altered cortisol secretion, but few studies
have investigated genetic variants in relation to both cortisol secretion and depression. To …

OBJECTIVE: We investigated whether treatment response is predicted by hypothalamus–
pituitary–adrenal (HPA) axis parameters, or by genetic polymorphisms in the glucocorticoid …