Polycystic kidney disease is a common genetic disorder in which fluid-filled cysts displace
normal renal tubules. Here we focus on autosomal dominant polycystic kidney disease …

New insights into the molecular pathophysiology of polycystic kidney disease. Polycystic
kidney diseases are characterized by the progressive expansion of multiple cystic lesions …

Polycystic kidney disease (PKD) is a life‐threatening genetic disorder characterized by the
presence of fluid‐filled cysts primarily in the kidneys. PKD can be inherited as autosomal …

Background Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy caused
by mutations in PKD1 and PKD2 that is characterized by renal tubular epithelial cell …

Naturally occurring mutations in two separate, but interacting loci, pkd1 and pkd2 are
responsible for almost all cases of autosomal dominant polycystic kidney disease (ADPKD) …

Autosomal dominant polycystic disease (ADPKD) is the most common form of inherited
kidney disease that results in renal failure. The understanding of the pathogenesis of …

The pathogenetic mechanisms underlying autosomal dominant polycystic kidney disease
(ADPKD) remain to be elucidated. While there is evidence that Pkd1 gene haploinsufficiency …

Autosomal dominant polycystic kidney disease, the most common monogenetic disorder, is
characterized by gradual replacement of normal renal parenchyma by fluid-filled cysts …

Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent, inherited condition
for which there is currently no effective specific clinical therapy. The disease is characterized …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common progressive
hereditary kidney disease. In 85–90% of cases, ADPKD results from a mutation in the PKD1 …