Chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq) has
become the dominant technique for mapping transcription factor (TF) binding regions …

Background The global effort to annotate the non-coding portion of the human genome
relies heavily on chromatin immunoprecipitation data generated with high-throughput DNA …

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is the most popular
assay to identify genomic regions, called ChIP-seq peaks, that are bound in vivo by …

Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) allows
researchers to determine the genome-wide binding locations of individual transcription …

Abstract The Encyclopedia of DNA Elements (ENCODE) consortium aims to identify all
functional elements in the human genome including transcripts, transcriptional regulatory …

Transcription factors (TFs) as key regulators play crucial roles in biological processes. The
identification of TF–target regulatory relationships is a key step for revealing functions of TFs …

Transcriptional regulation requires the binding of transcription factors (TFs) to short
sequence-specific DNA motifs, usually located at the gene regulatory regions. Interestingly …

We present a major update of the HOCOMOCO collection that consists of patterns
describing DNA binding specificities for human and mouse transcription factors. In this …

Regulation of gene transcription in diverse cell types is determined largely by varied sets of
cis-elements where transcription factors bind. Here we demonstrate that data from a single …

Gene regulatory programs in distinct cell types are maintained in large part through the cell-
type–specific binding of transcription factors (TFs). The determinants of TF binding include …