Mapping microRNA expression quantitative trait loci in the prenatal human brain implicates miR-1908-5p expression in bipolar disorder and other brain-related traits

CC Toste, MC O'Donovan… - Human Molecular Genetics, 2023 - academic.oup.com
MicroRNA (miRNA) are small non-coding RNA involved in post-transcriptional gene
regulation. Given their known involvement in early neurodevelopment processes, we here …

Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder

AJ Forstner, A Hofmann, A Maaser, S Sumer… - Translational …, 2015 - nature.com
Bipolar disorder (BD) is a severe and highly heritable neuropsychiatric disorder with a
lifetime prevalence of 1%. Molecular genetic studies have identified the first BD susceptibility …

Identification of differentially expressed microRNAs across the developing human brain

MN Ziats, OM Rennert - Molecular psychiatry, 2014 - nature.com
We present a spatio-temporal assessment of microRNA (miRNA) expression throughout
early human brain development. We assessed the prefrontal cortex, hippocampus and …

Heterogeneity and individuality: microRNAs in mental disorders

LG Hommers, K Domschke, J Deckert - Journal of neural transmission, 2015 - Springer
MicroRNAs are about 22 nucleotide long single-stranded RNA molecules, negatively
regulating gene expression of a single gene or a gene network. In neural tissues, they have …

Genetic regulation of microRNAs in the older adult brain and their contribution to neuropsychiatric conditions

SM Vattathil, ES Gerasimov, SM Canon, A Lori… - bioRxiv, 2024 - biorxiv.org
MicroRNAs are essential post-transcriptional regulators of gene expression and involved in
many biological processes; however, our understanding of their genetic regulation and role …

miRNA genes and the brain: implications for psychiatric disorders a

DA Forero, K van Der Ven, P Callaerts… - Human …, 2010 - Wiley Online Library
MicroRNAs (miRNAs) are a class of nonprotein coding genes with a growing importance in
regulatory mechanisms of gene expression related to brain function and plasticity …

Genetic and functional analyses implicate microRNA 499A in bipolar disorder development

A Tielke, H Martins, MA Pelzl, A Maaser-Hecker… - Translational …, 2022 - nature.com
Bipolar disorder (BD) is a complex mood disorder with a strong genetic component. Recent
studies suggest that microRNAs contribute to psychiatric disorder development. In BD …

MicroRNAs as biomarkers for psychiatric disorders with a focus on autism spectrum disorder: current progress in genetic association studies, expression profiling, and …

Y Hu, EA Ehli, DI Boomsma - Autism Research, 2017 - Wiley Online Library
MicroRNAs (miRNAs) are a group of small noncoding RNA molecules, 18–25 nucleotides in
length, which can negatively regulate gene expression at the post‐transcriptional level by …

Genetic variants in miRNAs differentially expressed during brain development and their relevance to psychiatric disorders susceptibility

CB Brum, VR Paixao-Cortes, AM Carvalho… - The World Journal of …, 2021 - Taylor & Francis
Objectives MicroRNAs (miRNAs) play an important regulatory role in the expression of
genes involved in brain functions during development. Genetic variants in miRNA genes …

Maturation of the human dorsolateral prefrontal cortex coincides with a dynamic shift in microRNA expression

NJ Beveridge, DM Santarelli, X Wang… - Schizophrenia …, 2014 - academic.oup.com
MicroRNA are small RNAs that provide specificity for the RNA induced silencing complex,
which forms the basis of an exquisite combinatorial system for posttranscriptional regulation …