Age is one of the most important prognostic factors associated to lethality in SARS-CoV-2
infection. In multivariate analysis, advanced age was an independent risk factor for death …

Oxidative stress and low-grade inflammation are the hallmarks of the aging process and are
even more enhanced in many age-related degenerative diseases. Mitochondrial dysfunction …

NLRP3 inflammasome is a critical immune component that plays a crucial role in mounting
innate immune responses. The deleterious effects of inflammasome activation have been …

Severe cases of COVID-19 are characterized by a strong inflammatory process that may
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …

Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

Highlights•SARS-CoV-2 infection in vitro triggers activation of the NLRP3
inflammasome.•The NLRP3 is activated in mice infected with SARS-CoV-2 and in the lungs …

Despite the fact that deregulated NLRP3 inflammasome activation contributes to the
pathogenesis of chronic inflammatory or metabolic disorders, the underlying mechanism by …

Severe SARS-CoV-2 infection causes systemic inflammation, cytokine storm, and
hypercytokinemia due to activation of the release of pro-inflammatory cytokines that have …

Despite a wealth of clinical data showing an association between inflammation and
degenerative disorders in the elderly, the immune sensors that causally link systemic …

Background The NLRP3 inflammasome is a sensor of specific pathogen, host and
environmental danger molecules. Upon activation NLRP3 recruits caspase-1, which cleaves …