Pyroptosis in sepsis induced organ dysfunction

R Song, S He, Y Wu, S Tan - Current Research in Translational Medicine, 2023 - Elsevier
As an uncontrolled inflammatory response to infection, sepsis and sepsis induced organ
dysfunction are great threats to the lives of septic patients. Unfortunately, the pathogenesis …

The role and mechanism of pyroptosis and potential therapeutic targets in sepsis: a review

X Zheng, W Chen, F Gong, Y Chen, E Chen - Frontiers in immunology, 2021 - frontiersin.org
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. Recently was been found that pyroptosis is a unique form of …

Molecular mechanisms and functions of pyroptosis in sepsis and sepsis-associated organ dysfunction

R Wen, YP Liu, XX Tong, TN Zhang… - Frontiers in Cellular and …, 2022 - frontiersin.org
Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to
infection, is a leading cause of death in intensive care units. The development of sepsis …

[HTML][HTML] Pyroptosis in septic lung injury: interactions with other types of cell death

Y Jiang, S Gao, Z Chen, X Zhao, J Gu, H Wu… - Biomedicine & …, 2023 - Elsevier
Sepsis is a life-threatening systemic inflammatory response syndrome caused by the host
imbalanced response to infection. Lung injury is the most common complication of sepsis …

The role of pyroptosis in inflammatory diseases

R Chai, Y Li, L Shui, L Ni, A Zhang - Frontiers in Cell and …, 2023 - frontiersin.org
Programmed cell death has crucial roles in the physiological maturation of an organism, the
maintenance of metabolism, and disease progression. Pyroptosis, a form of programmed …

Recent advances in the molecular mechanisms underlying pyroptosis in sepsis

YL Gao, JH Zhai, YF Chai - Mediators of inflammation, 2018 - Wiley Online Library
Sepsis is recognized as a life‐threatening organ dysfunctional disease that is caused by
dysregulated host responses to infection. Up to now, sepsis still remains a dominant cause …

Research progresses of molecular mechanism of pyroptosis and its related diseases

W Gong, Y Shi, J Ren - Immunobiology, 2020 - Elsevier
Pyroptosis is a newly discovered untypical form of programmed cell death by inflammatory
response, which is dependent on the classic pathway of Caspase-1 and the non-canonical …

Research progress of pyroptosis in sepsis

L Shen, L Li, J Yan - Zhonghua wei zhong bing ji jiu yi xue, 2019 - europepmc.org
Objective Sepsis is an organ dysfunction syndrome caused by an abnormal host immune
response because of infection. Pyroptosis is a newly discovered programmed cell death …

Pyroptosis: a promising therapeutic target for noninfectious diseases

T Li, G Zheng, B Li, L Tang - Cell proliferation, 2021 - Wiley Online Library
Pyroptosis, which is characterized by gasdermin family protein‐mediated pore formation,
cellular lysis and the release of pro‐inflammatory cytokines, is a form of programmed cell …

Role of pyroptosis in hemostasis activation in sepsis

C Zhu, Y Liang, Y Luo, X Ma - Frontiers in Immunology, 2023 - frontiersin.org
Sepsis is frequently associated with hemostasis activation and thrombus formation, and
systematic hemostatic changes are associated with a higher risk of mortality. The key events …