[PDF][PDF] Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases
SA Gagliano, JG Pouget, J Hardy… - Annals of clinical …, 2016 - Wiley Online Library
Objectives We assessed the current genetic evidence for the involvement of various cell
types and tissue types in the etiology of neurodegenerative diseases, especially in relation …
types and tissue types in the etiology of neurodegenerative diseases, especially in relation …
Genetics of neurodegenerative diseases: an overview
L Pihlstrøm, S Wiethoff, H Houlden - Handbook of clinical neurology, 2018 - Elsevier
Genetic factors are central to the etiology of neurodegeneration, both as monogenic causes
of heritable disease and as modifiers of susceptibility to complex, sporadic disorders. Over …
of heritable disease and as modifiers of susceptibility to complex, sporadic disorders. Over …
Heterogeneity and polygenicity in psychiatric disorders: a genome-wide perspective
Genome-wide association studies (GWAS) have been performed for many psychiatric
disorders and revealed a complex polygenic architecture linking mental and physical health …
disorders and revealed a complex polygenic architecture linking mental and physical health …
[HTML][HTML] Sex differences in brain protein expression and disease
Most complex human traits differ by sex, but we have limited insight into the underlying
mechanisms. Here, we investigated the influence of biological sex on protein expression …
mechanisms. Here, we investigated the influence of biological sex on protein expression …
Single-cell transcriptomic analysis of Alzheimer's disease
Alzheimer's disease is a pervasive neurodegenerative disorder, the molecular complexity of
which remains poorly understood. Here, we analysed 80,660 single-nucleus transcriptomes …
which remains poorly understood. Here, we analysed 80,660 single-nucleus transcriptomes …
Mouse models rarely mimic the transcriptome of human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models
Translational research for neurodegenerative disease depends intimately upon animal
models. Unfortunately, promising therapies developed using mouse models mostly fail in …
models. Unfortunately, promising therapies developed using mouse models mostly fail in …
Emerging phenotyping strategies will advance our understanding of psychiatric genetics
S Sanchez-Roige, AA Palmer - Nature neuroscience, 2020 - nature.com
Over the last decade, genome-wide association studies of psychiatric disorders have
identified numerous significant loci. Whereas these studies initially depended on cohorts …
identified numerous significant loci. Whereas these studies initially depended on cohorts …
Embracing polygenicity: a review of methods and tools for psychiatric genetics research
RM Maier, PM Visscher, MR Robinson… - Psychological …, 2018 - cambridge.org
The availability of genome-wide genetic data on hundreds of thousands of people has led to
an equally rapid growth in methodologies available to analyse these data. While the …
an equally rapid growth in methodologies available to analyse these data. While the …
[HTML][HTML] Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes
Background Human proteins are widely used as drug targets. Integration of large-scale
protein-level genome-wide association studies (GWAS) and disease-related GWAS has thus …
protein-level genome-wide association studies (GWAS) and disease-related GWAS has thus …