Motivation: Caspases and granzyme B (GrB) are important proteases involved in
fundamental cellular processes and play essential roles in programmed cell death, necrosis …

As one of the few irreversible protein posttranslational modifications, proteolytic cleavage is
involved in nearly all aspects of cellular activities, ranging from gene regulation to cell life …

Caspases and granzyme B are proteases that share the primary specificity to cleave at the
carboxyl terminal of aspartate residues in their substrates. Both, caspases and granzyme B …

Motivation: The caspase family of cysteine proteases play essential roles in key biological
processes such as programmed cell death, differentiation, proliferation, necrosis and …

Background Caspases are a family of proteases that have central functions in programmed
cell death (apoptosis) and inflammation. Caspases mediate their effects through aspartate …

Caspases are enzymes belonging to a conserved family of c ysteine-dependent asp artic-
specific prote ases that are involved in vital cellular processes and play a prominent role in …

Background Caspases are a family of cysteinyl proteases that regulate apoptosis and other
biological processes. Caspase-3 is considered the central executioner member of this family …

Background Caspases belong to a class of cysteine proteases which function as critical
effectors in cellular processes such as apoptosis and inflammation by cleaving substrates …

Abstract Motivation: Granzyme B (GrB) and caspases cleave specific protein substrates to
induce apoptosis in virally infected and neoplastic cells. While substrates for both types of …

Motivation: In vitro studies have shown that the most remarkable catalytic features of
caspases, a family of cysteineproteases, are their stringent specificity to Asp (D) in the S1 …