Facilitation of extinction of conditioned fear by D-cycloserine: Implications for psychotherapy

M Davis, KM Myers, KJ Ressler… - Current Directions in …, 2005 - journals.sagepub.com
Excessive fear and anxiety are characteristic of disorders such as post-traumatic stress
disorder (PTSD) and phobias and are believed to reflect abnormalities in neural systems …

Facilitation of fear extinction by D-cycloserine: theoretical and clinical implications

R Richardson, L Ledgerwood, J Cranney - Learning & Memory, 2004 - learnmem.cshlp.org
Anxiety disorders are among the most common psychological disturbances in the
industrialized world. Current behavioral therapy procedures for these disorders are …

D-cycloserine does not facilitate fear extinction by reducing conditioned stimulus processing or promoting conditioned inhibition to contextual cues

KD Baker, GP McNally, R Richardson - Learning & Memory, 2012 - learnmem.cshlp.org
The NMDA receptor partial agonist d-cycloserine (DCS) enhances the extinction of learned
fear in rats and exposure therapy in humans with anxiety disorders. Despite these benefits …

Effects of D-cycloserine on extinction: translation from preclinical to clinical work

M Davis, K Ressler, BO Rothbaum, R Richardson - Biological psychiatry, 2006 - Elsevier
Administration of benzodiazepines or serotonin reuptake inhibitors in combination with
behavior therapy for the treatment of many anxiety disorders has generally lead to only …

[HTML][HTML] D-cycloserine for treating anxiety disorders: making good exposures better and bad exposures worse

SG Hofmann - Depression and anxiety, 2014 - ncbi.nlm.nih.gov
In an attempt to improve the efficacy of psychotherapy for anxiety disorders, preclinical
paradigms have recent been translated into novel treatment strategies.[1] Specifically, these …

D-cycloserine facilitates extinction of learned fear: effects on reacquisition and generalized extinction

L Ledgerwood, R Richardson, J Cranney - Biological psychiatry, 2005 - Elsevier
BACKGROUND: d-cycloserine (DCS) facilitates extinction of learned fear. The aim of this
study was to examine whether DCS 1) affects reacquisition of fear (Experiment 1) and 2) …

D-Cycloserine as an augmentation strategy for cognitive behavioral therapy of anxiety disorders

SG Hofmann, JQ Wu, H Boettcher - Biology of Mood & Anxiety Disorders, 2013 - Springer
The goal of this review is to examine the clinical studies on d-cycloserine, a partial
glutamatergic N-methyl-D-aspartate agonist, as an augmentation strategy for exposure …

Enhancing exposure-based therapy from a translational research perspective

SG Hofmann - Behaviour research and therapy, 2007 - Elsevier
Combining an effective psychological treatment with conventional anxiolytic medication is
typically not more effective than unimodal therapy for treating anxiety disorders. However …

D-cycloserine facilitation of fear extinction and exposure-based therapy might rely on lower-level, automatic mechanisms

C Grillon - Biological psychiatry, 2009 - Elsevier
Exposure-based therapy, a leading technique in the treatment of a range of anxiety
disorders, is facilitated by D-cycloserine (DCS), a partial N-methyl-D-aspartate receptor …

D-cycloserine facilitates context-specific fear extinction learning

ME Bouton, D Vurbic, AM Woods - Neurobiology of learning and memory, 2008 - Elsevier
d-Cycloserine (DCS) may facilitate fear extinction learning, but the behavioral
consequences and mechanisms behind this effect are not well understood at present. In this …