Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner

A Comment, B van den Brandt… - … Resonance Part B …, 2007 - Wiley Online Library
For most of the last forty years, the techniques of Dynamic Nuclear Polarization (DNP) have
been confined to particle‐physics laboratories building polarized targets, but recently it has …

A multisample 7 T dynamic nuclear polarization polarizer for preclinical hyperpolarized MR

T Cheng, AP Gaunt, I Marco‐Rius… - NMR in …, 2020 - Wiley Online Library
Dynamic nuclear polarization (DNP) provides the opportunity to boost liquid state magnetic
resonance (MR) signals from selected nuclear spins by several orders of magnitude. A …

Generating highly polarized nuclear spins in solution using dynamic nuclear polarization

J Wolber, F Ellner, B Fridlund, A Gram… - Nuclear Instruments and …, 2004 - Elsevier
A method to generate strongly polarized nuclear spins in solution has been developed,
using Dynamic Nuclear Polarization (DNP) at a temperature of 1.2 K, and at a field of 3.354 …

A multi-sample 94 GHz dissolution dynamic-nuclear-polarization system

M Batel, M Krajewski, K Weiss, O With, A Däpp… - Journal of magnetic …, 2012 - Elsevier
We describe the design and initial performance results of a multi-sample dissolution
dynamic-nuclear-polarization (DNP) polarizer based on a Helium-temperature NMR cryostat …

[HTML][HTML] An automated system for fast transfer and injection of hyperpolarized solutions

M Ceillier, O Cala, T El Daraï, SF Cousin… - Journal of Magnetic …, 2021 - Elsevier
Dissolution dynamic nuclear polarization (dDNP) has become a hyperpolarization method of
choice for enhancing nuclear magnetic resonance (NMR) signals. Nuclear spins are …

Design and performance of a small bath cryostat with NMR capability for transport of hyperpolarized samples

A Capozzi - Scientific Reports, 2022 - nature.com
As of today, dissolution Dynamic Nuclear Polarization (dDNP) is the only clinically available
hyperpolarization technique for 13C-MRI. Despite the clear path towards personalized …

Cryogen‐free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T

JH Ardenkjær‐Larsen, S Bowen… - Magnetic …, 2019 - Wiley Online Library
Purpose A novel dissolution dynamic nuclear polarization (dDNP) polarizer platform is
presented. The polarizer meets a number of key requirements for in vitro, preclinical, and …

High-field dynamic nuclear polarization for solid and solution biological NMR

AB Barnes, G De Paëpe, PCA Van Der Wel… - Applied magnetic …, 2008 - Springer
Dynamic nuclear polarization (DNP) results in a substantial nuclear polarization
enhancement through a transfer of the magnetization from electrons to nuclei. Recent years …

Producing over 100 ml of highly concentrated hyperpolarized solution by means of dissolution DNP

A Comment, J Rentsch, F Kurdzesau, S Jannin… - Journal of magnetic …, 2008 - Elsevier
New low-temperature inserts compatible with an existing hyperpolarizer were developed to
dynamically polarize nuclei in large samples. The performance of the system was tested on …

DNP in MRI: An in-bore approach at 1.5 T

JG Krummenacker, VP Denysenkov, M Terekhov… - Journal of Magnetic …, 2012 - Elsevier
We have used liquid state (“Overhauser”) Dynamic Nuclear Polarization (DNP) to
significantly enhance the signal to noise ratio (SNR) of Magnetic Resonance Imaging (MRI) …