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Although adaptive design methods are flexible and useful in clinical research, little or no
regulatory guidelines are available. One of the first books on the topic, Adaptive Design …

Adaptive designs promise the flexibility to redesign clinical trials at interim stages. This
flexibility would provide greater efficiency in drug development. However, despite this …

Adaptive designs allow planned modifications based on data accumulating within a study.
The promise of greater flexibility and efficiency stimulates increasing interest in adaptive …

Adaptive designs can make clinical trials more flexible by utilising results accumulating in
the trial to modify the trial's course in accordance with pre-specified rules. Trials with an …

Adaptive designs for clinical trials permit alterations to a study in response to accumulating
data in order to make trials more flexible, ethical, and efficient. These benefits are achieved …

Adaptive clinical trials are an innovative trial design aimed at reducing resources,
decreasing time to completion and number of patients exposed to inferior interventions, and …

Background Adaptive designs are a wide class of methods focused on improving the power,
efficiency and participant benefit of clinical trials. They do this through allowing information …

Adaptive designs play an increasingly important role in clinical drug development. Such
designs use accumulating data of an ongoing trial to decide how to modify design aspects …

Adaptive designs have the potential to improve efficiency in the evaluation of new medical
treatments in comparison to traditional fixed sample size designs. However, they are still not …