SARS‐CoV‐2 and SARS‐CoV: Virtual screening of potential inhibitors targeting RNA‐dependent RNA polymerase activity (NSP12)

Z Ruan, C Liu, Y Guo, Z He, X Huang… - Journal of medical …, 2021 - Wiley Online Library
Since the outbreak of severe acute respiratory syndrome (SARS) in 2003, the harm caused
by coronaviruses to the world cannot be underestimated. Recently, a novel coronavirus …

New targets for drug design: importance of nsp14/nsp10 complex formation for the 3'‐5'exoribonucleolytic activity on SARS‐CoV‐2

M Saramago, C Bárria, VG Costa, CS Souza… - The FEBS …, 2021 - Wiley Online Library
SARS‐CoV‐2 virus has triggered a global pandemic with devastating consequences. The
understanding of fundamental aspects of this virus is of extreme importance. In this work, we …

[HTML][HTML] Potential treatment with Chinese and Western medicine targeting NSP14 of SARS-CoV-2

C Liu, X Zhu, Y Lu, X Zhang, X Jia, T Yang - Journal of pharmaceutical …, 2021 - Elsevier
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is a serious global health threat. This raises an …

Potential inhibitors of SARS-cov-2 RNA dependent RNA polymerase protein: molecular docking, molecular dynamics simulations and MM-PBSA analyses

Z Elkarhat, H Charoute, L Elkhattabi… - Journal of …, 2022 - Taylor & Francis
The SARS-cov-2 RNA dependent RNA polymerase (nsp12) is a crucial viral enzyme that
catalyzes the replication of RNA from RNA templates. The fixation of some ligands in the …

Structure-based drug repurposing for targeting Nsp9 replicase and spike proteins of severe acute respiratory syndrome coronavirus 2

V Chandel, PP Sharma, S Raj… - Journal of …, 2022 - Taylor & Francis
Drug re-purposing might be a fast and efficient way of drug development against the novel
coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 …

SARS-CoV-2 nsp5 exhibits stronger catalytic activity and interferon antagonism than its SARS-CoV ortholog

J Chen, Z Li, J Guo, S Xu, J Zhou, Q Chen… - Journal of …, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose an
enormous threat to economic activity and public health worldwide. Previous studies have …

Virtual screening, ADME/T, and binding free energy analysis of anti-viral, anti-protease, and anti-infectious compounds against NSP10/NSP16 methyltransferase and …

SK Maurya, AK Maurya, N Mishra… - Journal of Receptors …, 2020 - Taylor & Francis
Recently, a pathogen has been identified as a novel coronavirus (SARS-CoV-2) and found
to trigger novel pneumonia (COVID-19) in human beings and some other mammals. The …

[PDF][PDF] The molecular docking study of potential drug candidates showing anti-COVID-19 activity by exploring of therapeutic targets of SARS-CoV-2

RR Narkhede, RS Cheke, JP Ambhore… - Eurasian J. Med …, 2020 - academia.edu
Objectives: The novel human coronavirus designated severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) first emerged in late 2019 in Wuhan, China. This virus spread …

In silico structure modelling of SARS-CoV-2 Nsp13 helicase and Nsp14 and repurposing of FDA approved antiviral drugs as dual inhibitors

AB Gurung - Gene reports, 2020 - Elsevier
The high mortality rate from the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infections in humans and the lack of effective therapeutic regime for its treatment …

The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent

AJW Te Velthuis, JJ Arnold, CE Cameron… - Nucleic acids …, 2010 - academic.oup.com
An RNA-dependent RNA polymerase (RdRp) is the central catalytic subunit of the RNA-
synthesizing machinery of all positive-strand RNA viruses. Usually, RdRp domains are …