Neutrophils and neutrophil extracellular traps drive necroinflammation in COVID-19

B Tomar, HJ Anders, J Desai, SR Mulay - Cells, 2020 - mdpi.com
The COVID-19 pandemic is progressing worldwide with an alarming death toll. There is an
urgent need for novel therapeutic strategies to combat potentially fatal complications …

Neutrophils in COVID-19: recent insights and advances

J Li, K Zhang, ye Zhang, Z Gu, C Huang - Virology journal, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can lead to acute …

Increased peripheral blood neutrophil activation phenotypes and neutrophil extracellular trap formation in critically ill coronavirus disease 2019 (COVID-19) patients: a …

JA Masso-Silva, A Moshensky, MTY Lam… - Clinical Infectious …, 2022 - academic.oup.com
Background Increased inflammation has been well defined in coronavirus disease 2019
(COVID-19), while definitive pathways driving severe forms of this disease remain uncertain …

Neutrophils in COVID-19: not innocent bystanders

E McKenna, R Wubben, JM Isaza-Correa… - Frontiers in …, 2022 - frontiersin.org
Unusually for a viral infection, the immunological phenotype of severe COVID-19 is
characterised by a depleted lymphocyte and elevated neutrophil count, with the neutrophil …

COVID‐19 and neutrophils: the relationship between hyperinflammation and neutrophil extracellular traps

L Borges, TC Pithon-Curi, R Curi… - Mediators of …, 2020 - Wiley Online Library
Coronavirus disease 2019 (COVID‐19) is a virus‐induced respiratory disease that may
progress to acute respiratory distress syndrome (ARDS) and is triggered by …

[HTML][HTML] Neutrophils and COVID-19: The road so far

LHA Cavalcante-Silva, DCM Carvalho… - International …, 2021 - Elsevier
The SARS-Cov2 infection triggers a multisystem inflammatory disorder, knowing as COVID-
19, a pandemic disease. This disease is characterized by acute respiratory distress …

Neutrophils in COVID-19

N Reusch, E De Domenico, L Bonaguro… - Frontiers in …, 2021 - frontiersin.org
Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …

Patients with COVID-19: in the dark-NETs of neutrophils

M Ackermann, HJ Anders, R Bilyy, GL Bowlin… - Cell Death & …, 2021 - nature.com
SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …

Neutrophils and lymphopenia, an unknown axis in severe COVID-19 disease

HF Peñaloza, JS Lee, P Ray - PLoS pathogens, 2021 - journals.plos.org
The Coronavirus Disease 2019 (COVID-19) is caused by the betacoronavirus Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus that can mediate asymptomatic or …

A neutrophil activation signature predicts critical illness and mortality in COVID-19

ML Meizlish, AB Pine, JD Bishai, G Goshua… - Blood …, 2021 - ashpublications.org
Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-
19, but the mechanisms involved remain poorly understood. We carried out proteomic …