The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications

E Guyot, A Chevallier, R Barouki, X Coumoul - Drug discovery today, 2013 - Elsevier
The aryl hydrocarbon receptor (AhR) is a transcription factor which is activated by diverse
compounds and regulates the expression of xenobiotic metabolism genes. Recent studies …

Ligands and agonists of the aryl hydrocarbon receptor AhR: Facts and myths

L Sládeková, S Mani, Z Dvořák - Biochemical Pharmacology, 2023 - Elsevier
The aryl hydrocarbon receptor (AhR) belongs to the essential helix-loop-helix transcription
factors family. This receptor has a central role in determining host physiology and a variety of …

The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic value

ÁC Roman, JM Carvajal-Gonzalez, JM Merino… - Pharmacology & …, 2018 - Elsevier
The aryl hydrocarbon receptor (AhR) is well-known for its major contributions to the cellular
responses against environmental toxins and carcinogens. Notably, AhR has also emerged …

Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway

NC Sondermann, S Faßbender, F Hartung… - Biochemical …, 2023 - Elsevier
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor regulating
adaptive and maladaptive responses toward exogenous and endogenous signals …

[HTML][HTML] Species-specific differences in aryl hydrocarbon receptor responses: how and why?

X Xu, X Zhang, Y Yuan, Y Zhao, HM Fares… - International Journal of …, 2021 - mdpi.com
The aryl hydrocarbon receptor (AhR) is a transcription factor that regulates a wide range of
biological and toxicological effects by binding to specific ligands. AhR ligands exist in …

An introduction to the molecular basics of aryl hydrocarbon receptor biology

J Abel, T Haarmann-Stemmann - 2010 - degruyter.com
Depending on their chemical structure and properties, environmental chemicals and other
xenobiotics that enter the cell can affect cellular function by either nonselective binding to …

Regulating the regulator: factors that control levels and activity of the aryl hydrocarbon receptor

PA Harper, DS Riddick, AB Okey - Biochemical pharmacology, 2006 - Elsevier
The aryl hydrocarbon receptor (AHR) participates in a wide range of critical cellular events in
response to endogenous signals or xenobiotic chemicals. Hence, it is important that AHR …

[PDF][PDF] The aryl hydrocarbon receptor complex

O Hankinson - Annual review of pharmacology and toxicology, 1995 - researchgate.net
The heterorneric unliganded aryl hydrocarbon receptor complex (AHRC) con t ains the aryl
hydrocarbon receptor monomer (AHR). Binding of polycyclic or halogenated aromatic …

[HTML][HTML] Old receptor, new tricks—the ever-expanding universe of aryl hydrocarbon receptor functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris …

C Esser, BP Lawrence, DH Sherr, GH Perdew, A Puga… - 2018 - mdpi.com
In a time where “translational” science has become a mantra in the biomedical field, it is
reassuring when years of research into a biological phenomenon suddenly points towards …

Endogenous and exogenous ligands of aryl hydrocarbon receptor: current state of art

L Stejskalova, Z Dvorak, P Pavek - Current drug metabolism, 2011 - ingentaconnect.com
Aryl hydrocarbon receptor (AhR) is an important transcriptional regulator of drug
metabolizing enzymes that dominantly controls the expression of cytochrome P450 CYP1 …