Highly pigmented, dark skin is more resistant to the harmful effects of solar ultraviolet
radiation than light-colored human skin. The extent to which tanning protects skin from …

Melanins, pigments of photoprotection and camouflage, are very photoreactive and can both
absorb and emit active oxygen species. Nevertheless, black skinned individuals rarely …

Epidermal melanin pigment is believed to prevent development of ultraviolet (UV)–induced
skin cancer by shielding cell nuclei and reducing DNA damage formation. It has not been …

Melanin is thought to serve in photoprotection. To investigate this, we have compared the
responses of cultured human melanocytes derived from different pigmentary phenotypes …

Melanomas occur mainly in sunlight-exposed skin. Xeroderma pigmentosum (XP) patients
have 1,000-fold higher incidence of melanoma, suggesting that sunlight-induced “bulky” …

The premutagenic oxidative DNA base damage, 7, 8-dihydro-8-oxoguanine, is induced in
human skin fibroblasts by monochromatic radiation ranging from a UVB wavelength (312 …

Ultraviolet light has been implicated as a dominant factor in skin cancer development. Skin
pigmentation is traditionally regarded as an important protection against skin cancer. Yet …

We previously developed a quantitative autoradiographic technique with special forceps for
measuring unscheduled DNA synthesis (UDS) in mouse skin after treatment with ultraviolet …

ABSTRACT DNA damage induced by UV radiation is a critical event in skin
photocarcinogenesis. However, the role of racial/ethnic origin in determining individual UV …

Melanin can form supranuclear caps in human epidermis, suggesting that intracellular
melanin reduces ultraviolet transmission to underlying cell nuclei and inhibits the formation …