Future directions for drug transporter modelling
Since the late 1980s computational methods such as quantitative structure–activity
relationship (QSAR) and pharmacophore approaches have become more widely applied to …
relationship (QSAR) and pharmacophore approaches have become more widely applied to …
Physiologically based pharmacokinetic modeling of drug transporters to facilitate individualized dose prediction
Physiologically based pharmacokinetic modeling is a commonly used strategy in the drug
development and regulatory submissions. This commentary provides a critical overview of …
development and regulatory submissions. This commentary provides a critical overview of …
Computational modeling to accelerate the identification of substrates and inhibitors for transporters that affect drug disposition
We have seen an increased use of computational approaches to predicting drug interactions
with human transporters that affect drug disposition and may lead to toxicity. These …
with human transporters that affect drug disposition and may lead to toxicity. These …
Computational approaches to modeling drug transporters
Computational modeling has advanced our understanding of drug absorption, tissue
distribution, excretion and toxicity profiles by providing both direct and indirect knowledge of …
distribution, excretion and toxicity profiles by providing both direct and indirect knowledge of …
The application of physiologically based pharmacokinetic modeling to predict the role of drug transporters: scientific and regulatory perspectives
Transporters play an important role in drug absorption, disposition, and drug action. The
evaluation of drug transporters requires a comprehensive understanding of transporter …
evaluation of drug transporters requires a comprehensive understanding of transporter …
Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions
Purpose Membrane transporters mediate many biological effects of chemicals and play a
major role in pharmacokinetics and drug resistance. The selection of viable drug candidates …
major role in pharmacokinetics and drug resistance. The selection of viable drug candidates …
Physiologically-based pharmacokinetic (PBPK) modelling of transporter mediated drug absorption, clearance and drug-drug interactions
KS Taskar, I Harada, RV Alluri - Current Drug Metabolism, 2021 - ingentaconnect.com
Membrane transporters play an important role in intestinal absorption, distribution and
clearance of drugs. Additionally transporters along with enzymes regulate tissue exposures …
clearance of drugs. Additionally transporters along with enzymes regulate tissue exposures …
Modeling of drug-transporter interactions using structural information.
S Winiwarter, C Hilgendorf - Current opinion in drug discovery & …, 2008 - europepmc.org
Drug-transporter interactions have recently been demonstrated to play an important part in
multidrug resistance, drug-drug interactions and drug disposition. Such interactions can …
multidrug resistance, drug-drug interactions and drug disposition. Such interactions can …
ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport‐mediated PK and DDIs in humans
MJ Zamek‐Gliszczynski, CA Lee… - Clinical …, 2013 - Wiley Online Library
This white paper provides a critical analysis of methods for estimating transporter kinetics
and recommendations on proper parameter calculation in various experimental systems …
and recommendations on proper parameter calculation in various experimental systems …
Computational modeling to predict the functions and impact of drug transporters
P Matsson, CAS Bergström - In silico pharmacology, 2015 - Springer
Transport proteins are important mediators of cellular drug influx and efflux and play crucial
roles in drug distribution, disposition and clearance. Drug-drug interactions have …
roles in drug distribution, disposition and clearance. Drug-drug interactions have …