For many years primary aldosteronism was considered a relatively benign form of
hypertension. This assumption reflects the primacy accorded to elevated levels of …

For many years, primary aldosteronism was thought (and taught) to be a relatively rare (<
1%) and benign form of high blood pressure: now we know that neither is the case …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Blockade of the renin-angiotensin-aldosterone system with angiotensin-converting enzyme
(ACE) inhibitors or angiotensin receptor antagonists has resulted in beneficial effects in …

Since its initial description in 1955, primary aldosteronism was thought to be a rare cause of
hypertension. However, with improved screening methodologies, it appears that primary …

Patients presenting with primary aldosteronism experience more cardiovascular events than
patients with essential hypertension independent of blood pressure. Therefore, the presence …

The main effects of aldosterone, the most physiologically important mineralocorticoid, are on
electrolyte transport across epithelia, particularly in the kidney, but also in other tissues, such …

Primary aldosterone excess or hyperaldosteronism is an important cause of hypertension
which, when associated with an aldosterone secreting adenoma, is amenable to surgical …

After the first cases of primary aldosteronism were described and characterized by Conn, a
substantial body of experimental and clinical evidence about the long-term effects of excess …

Purpose Use of the aldosterone-to-renin ratio (ARR) has suggested that at least one in 10
hypertensive subjects have primary aldosteronism (PA). There is thus a timely need to …