Novel bispecific human antibody platform specifically targeting a fully open spike conformation potently neutralizes multiple SARS-CoV-2 variants

JW Kim, K Heo, HJ Kim, Y Yoo, HS Cho, HJ Jang… - Antiviral Research, 2023 - Elsevier
Rapid emergence of new variants of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has prompted an urgent need for the development of broadly applicable and …

Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

H Cho, KK Gonzales-Wartz, D Huang, M Yuan… - Science translational …, 2021 - science.org
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
of concern threatens the efficacy of existing vaccines and therapeutic antibodies and …

An engineered IgG–VHH bispecific antibody against SARS‐CoV‐2 and its variants

H Chi, L Wang, C Liu, X Cheng, H Zheng, L Lv… - Small …, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) neutralizing antibodies
are shown to be effective therapeutics for providing coronavirus disease 2019 (COVID‐19) …

Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes

D Fu, G Zhang, Y Wang, Z Zhang, H Hu, S Shen… - PLoS …, 2021 - journals.plos.org
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) threatens global public health and …

A novel bispecific antibody dual-targeting approach for enhanced neutralization against fast-evolving SARS-CoV-2 variants

JW Kim, HJ Kim, K Heo, Y Lee, HJ Jang… - Frontiers in …, 2023 - frontiersin.org
Introduction The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants has caused unprecedented health and socioeconomic crises, necessitating …

Structure-guided antibody cocktail for prevention and treatment of COVID-19

SC Su, TJ Yang, PY Yu, KH Liang, WY Chen… - PLoS …, 2021 - journals.plos.org
Development of effective therapeutics for mitigating the COVID-19 pandemic is a pressing
global need. Neutralizing antibodies are known to be effective antivirals, as they can be …

[HTML][HTML] Identification of human single-domain antibodies against SARS-CoV-2

Y Wu, C Li, S Xia, X Tian, Y Kong, Z Wang, C Gu… - Cell host & …, 2020 - cell.com
The worldwide spread of COVID-19 highlights the need for an efficient approach to rapidly
develop therapeutics and prophylactics against SARS-CoV-2. The SARS-CoV-2 spike …

[HTML][HTML] Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

H Cho, KK Gonzales-Wartz, D Huang, M Yuan… - bioRxiv, 2021 - ncbi.nlm.nih.gov
The emergence of SARS-CoV-2 variants that threaten the efficacy of existing vaccines and
therapeutic antibodies underscores the urgent need for new antibody-based tools that …

IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern

MR Chang, L Tomasovic, NA Kuzmina, AJ Ronk… - Nature …, 2022 - nature.com
Monoclonal antibodies are a promising approach to treat COVID-19, however the
emergence of SARS-CoV-2 variants has challenged the efficacy and future of these …

A bispecific antibody targeting RBD and S2 potently neutralizes SARS-CoV-2 Omicron and other variants of concern

M Yuan, X Chen, Y Zhu, X Dong, Y Liu, Z Qian… - Journal of …, 2022 - Am Soc Microbiol
Emerging severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants,
especially the Omicron variant, have impaired the efficacy of existing vaccines and most …