Understanding human embryology has historically relied on comparative approaches using
mammalian model organisms. With the advent of low-input methods to investigate genetic …

The mouse embryo is the canonical model for mammalian preimplantation development.
Recent advances in single cell profiling allow detailed analysis of embryogenesis in other …

Early mammalian embryogenesis is controlled by mechanisms governing the balance
between pluripotency and differentiation. The expression of early lineage-specific genes can …

Studies of cultured embryos have provided insights into human peri-implantation
development. However, detailed knowledge of peri-implantation lineage development as …

Preimplantation development is marked by four major events: the transition of maternal
transcripts to zygotic transcripts, compaction, the first lineage differentiation into inner cell …

Recent years have seen exciting progress across human embryo research, including new
methods for culturing embryos, transcriptional profiling of embryogenesis and gastrulation …

Successful human development is dependent upon a cascade of events following
fertilization. Unfortunately, knowledge of these critical events in humans is remarkably …

Background Preimplantation development is a crucial step in early human development.
However, the molecular basis of human preimplantation development is not well known …

Genome-wide expression analysis of embryonic development provides information that is
useful in a variety of contexts. Here, we report transcriptome profiles of human early embryos …

After fertilization, mouse embryos go through preimplantation development to give rise to
blastocyst. Two key molecular events, zygotic genome activation (ZGA) and the first cell …