The concept of a systemic inflammatory response syndrome (SIRS) to describe the complex
pathophysiologic response to an insult such as infection, trauma, burns, pancreatitis, or a …

Despite widespread advances in intensive care practices, and more potent and effective
antimicrobials, septic shock continues to have a mortality rate of greater than 40%. Although …

Systemic inflammatory response syndrome (SIRS) is the clinical expression of the action of
complex intrinsic mediators of the acute phase reaction. SIRS can be precipitated by events …

Objective.—Define the epidemiology of the four recently classified syndromes describing the
biologic response to infection: systemic inflammatory response syndrome (SIRS), sepsis …

Autoinflammation as a distinct disease category was first reported in 1999 as a group of
monogenic disorders characterized by recurrent episodes of systemic and organ-specific …

Objective To find serologic markers of disease activity in patients with Churg‐Strauss
syndrome (CSS) linked to possible pathogenetic mechanisms by studying endothelial cell …

Our current understanding of sepsis and multiple organ dysfunction needs to be revised, as
the uniformly negative results of new therapies for these disorders suggest. Previous …

Sepsis is associated with an exacerbated production of both pro-and anti-inflammatory
cytokines, which are detectable within the bloodstream. Their'half-angel, half-devil'properties …

Objective. To assess the effects prospectively of tumour necrosis factor (TNF) receptor
superfamily (TNFRSF) fusion proteins TNFRSF1B (etanercept) and TNFRSF1A (p55TNFr …

Progress in the care of the critically ill patient with life-threatening infection has been
hampered by inconsistent, often confusing terminology. The clinical syndrome of sepsis …