Inflammatory bowel disease: exploring gut pathophysiology for novel therapeutic targets

V Yadav, F Varum, R Bravo, E Furrer, D Bojic… - Translational …, 2016 - Elsevier
Ulcerative colitis and Crohn's disease are the 2 major phenotypes of inflammatory bowel
disease (IBD), which are influenced by a complex interplay of immunological and genetic …

New insights into inflammatory bowel disease pathophysiology: paving the way for novel therapeutic targets

T Stefanelli, A Malesci, A Repici, S Vetrano… - Current Drug …, 2008 - ingentaconnect.com
The etiopathogenesis of Crohn's disease (CD) and ulcerative Colitis (UC), the two major
forms of inflammatory bowel disease (IBD), is still unknown. Although the exact cause and …

New pathophysiological insights and modern treatment of IBD

MA Engel, MF Neurath - Journal of gastroenterology, 2010 - Springer
Inflammatory bowel disease (IBD), which comprises two main types, namely, Crohn's
disease and ulcerative colitis, affects approximately 3.6 million people in the USA and …

Pathogenesis of inflammatory bowel disease and recent advances in biologic therapies

DH Kim, JH Cheon - Immune network, 2017 - synapse.koreamed.org
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder with an
unknown etiology. IBD is composed of two different disease entities: Crohn's disease (CD) …

Evolving paradigms in the pathogenesis of IBD

L Mayer - Journal of gastroenterology, 2010 - Springer
The pathogenesis of all immune-mediated inflammatory diseases has been carefully studied
over the past several decades, but it is only recently that we have come to appreciate …

A comprehensive review and update on the pathogenesis of inflammatory bowel disease

Q Guan - Journal of immunology research, 2019 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic and life‐threating inflammatory disease of
gastroenteric tissue characterized by episodes of intestinal inflammation. The pathogenesis …

New insights into the pathophysiology of inflammatory bowel disease: microbiota, epigenetics and common signalling pathways

G Rogler, L Biedermann, M Scharl - Swiss medical weekly, 2018 - zora.uzh.ch
The exact pathophysiology of inflammatory bowel disease (IBD) is still unknown. However,
over the years important insights allowed the development of novel therapeutic approaches …

Recent understanding of IBD pathogenesis: implications for future therapies

T Kucharzik, C Maaser, A Lügering… - Inflammatory bowel …, 2006 - academic.oup.com
The inflammatory bowel diseases (IBD) are comprised of two major phenotypes, Crohn's
disease (CD) and ulcerative colitis (UC). Research over the last couple of years has led to …

Pathway-based approaches to the treatment of inflammatory bowel disease

G Bamias, TT Pizarro, F Cominelli - Translational Research, 2016 - Elsevier
Crohn's disease and ulcerative colitis, collectively termed inflammatory bowel disease (IBD),
are immunologic disorders that represent the prototypes of chronic intestinal inflammation …

Inflammatory bowel disease: past, present, and future

BE Sands - Journal of gastroenterology, 2007 - Springer
Crohn's disease and ulcerative colitis, collectively known as the inflammatory bowel
diseases (IBD), are largely diseases of the twentieth century, and are associated with the …