Blood–brain barrier dysfunction in brain diseases: Clinical experience

K Schoknecht, H Shalev - Epilepsia, 2012 - Wiley Online Library
The blood–brain barrier, a unique feature of the cerebral vasculature, is gaining attention as
a feature in common neurologic disorders including stroke, traumatic brain injury, epilepsy …

Blood-brain barrier integrity and glial support: mechanisms that can be targeted for novel therapeutic approaches in stroke

PT Ronaldson, TP Davis - Current pharmaceutical design, 2012 - ingentaconnect.com
The blood-brain barrier (BBB) is a critical regulator of brain homeostasis. Additionally, the
BBB is the most significant obstacle to effective CNS drug delivery. It possesses specific …

The blood–brain barrier—gatekeeper to neuronal homeostasis: clinical implications in the setting of stroke

K Schoknecht, Y David, U Heinemann - Seminars in cell & developmental …, 2015 - Elsevier
The blood–brain barrier is part of the neurovascular unit and serves as a functional and
anatomical barrier between the blood and the extracellular space. It controls the flow of …

Blood–brain barrier imaging in human neuropathologies

R Veksler, I Shelef, A Friedman - Archives of medical research, 2014 - Elsevier
The blood–brain barrier (BBB) is essential for normal function of the brain, and its role in
many brain pathologies has been the focus of numerous studies during the last decades …

Imaging blood–brain barrier dysfunction in animal disease models

A Wunder, K Schoknecht, DB Stanimirovic, O Prager… - …, 2012 - Wiley Online Library
The blood–brain barrier (BBB) is a highly complex structure, which separates the
extracellular fluid of the central nervous system (CNS) from the blood of CNS vessels. A …

Blood–brain barrier breakdown in acute and chronic cerebrovascular disease

Y Yang, GA Rosenberg - Stroke, 2011 - Am Heart Assoc
Disruptions of the blood–brain barrier (BBB) and edema formation both play key roles in the
development of neurological dysfunction in acute and chronic cerebral ischemia. Animal …

The blood–brain barrier

B Obermeier, A Verma, RM Ransohoff - Handbook of clinical neurology, 2016 - Elsevier
In autoimmune neurologic disorders, the blood–brain barrier (BBB) plays a central role in
immunopathogenesis, since this vascular interface is an entry path for cells and effector …

Translational stroke research on blood-brain barrier damage: challenges, perspectives, and goals

Y Shi, RK Leak, RF Keep, J Chen - Translational Stroke Research, 2016 - Springer
Over the past few decades, basic and clinical research has identified numerous risk factors
for the development of stroke and led to major improvements in health management in the …

Inflammatory events at blood–brain barrier in neuroinflammatory and neurodegenerative disorders: implications for clinical disease

HE de Vries, G Kooij, D Frenkel, S Georgopoulos… - …, 2012 - Wiley Online Library
Proper function of the neurovasculature is required for optimal brain function and preventing
neuroinflammation and neurodegeneration. Within this review, we discuss alterations of the …

The blood–brain barrier in health and disease: Important unanswered questions

CP Profaci, RN Munji, RS Pulido… - Journal of Experimental …, 2020 - rupress.org
The blood vessels vascularizing the central nervous system exhibit a series of distinct
properties that tightly control the movement of ions, molecules, and cells between the blood …