Given that the genetic risk for schizophrenia is highly polygenic and the effect sizes, even for
rare or de novo events, are modest at best, it has been suggested that multiple biological …

Schizophrenia is a highly polygenic brain disorder. The main hypothesis for disease etiology
in schizophrenia primarily focuses on the role of dysfunctional synaptic transmission …

Schizophrenia, a debilitating disease with 1% prevalence in the general population, is
characterized by major neuropsychiatric symptoms, including delusions, hallucinations, and …

Background The quest to understand the neurobiology of schizophrenia and bipolar
disorder is ongoing with multiple lines of evidence indicating abnormalities of glia …

Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …

Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …

Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …

The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

Multiple neurotransmitter circuits are disturbed in schizophrenia, and the dopamine
hypothesis of schizophrenia prevails as the hypothesis with most empirical support. On the …

Numerous genetic risk loci are found to associate with major neuropsychiatric disorders
represented by schizophrenia. The pathogenic roles of genetic risk loci in psychiatric …