Unfortunately, the contribution of the majority of association studies so far to our
understanding of the genetic determinants of hypertension remains largely negligible. For …

Despite the availability of a plethora of very effective antihypertensive drugs, the treatment of
hypertension remains suboptimal and the prevalence of hypertension is increasing [1, 2]. In …

Hypertension is a complex genetic disorder caused by interplay between several 'risk'genes
and environmental factors (genetic heritability∼ 30%). Most genetic studies of hypertension …

Gene expression differences accompany both the onset and established phases of
hypertension. By an integrated genome-transcriptome approach we performed a meta …

Human essential hypertension is a complex, multifactorial, quantitative trait under a
polygenic control. Over the last decade several strategies have been used to dissect the …

Epidemiological studies have shown that blood pressure and electrolyte excretion vary
across different races and ethnicities. 1 Understanding the molecular basis for these …

Monogenic forms of hypertension are very rare, but have a well-characterized heredity.
Primary hypertension is very common with a complex and polygenic heredity. Primary …

We are at the beginning of a biological revolution, spurred on by the Human Genome
Project and associated studies. Within the next few years, expressed sequence tags (ESTs) …

PHYSIOLOGISTS HAVE LONG APPRECIATED the central role of renal salt excretion in the
control of blood pressure (4). Maintenance of a constant intravascular fluid volume and …

Genome-wide linkage analysis was performed for systolic and diastolic blood pressures in
the Hypertension Genetic Epidemiology Network. We investigated the role of gene–age …