Hypertension represents the upper range of the continuous distribution of blood pressure
seen in human populations. High blood pressure is a multifactorial trait requiring both …

Introduction: The study of polymorphisms of genes responsible for the development of
arterial hypertension is a promising direction of medicine. Hypertension is a multifactorial …

Introduction: Essential hypertension (HTN) is a multifactorial disease involving
environmental, genetic and other factors. Over the past years, genetic studies of essential …

Abstract Purpose of Review Here, we discuss the interpretation and modeling of gene-
environment interactions in hypertension-related phenotypes, with a focus on the necessary …

Compelling evidence for the inherited nature of essential hypertension has led to extensive
research in rats and humans. Rats have served as the primary model for research on the …

It may be unrealistic to expect a pure monogenic (single gene) explanation for most patients
with a disorder as common and heterogeneous as essential hypertension. However, gene …

The genetics of essential hypertension has proven refractory to molecular and
epidemiological genetic approaches despite the early successes in identifying the genes …

Several recent studies have provided insights into the genetic regulation of blood pressure.
A new study extends these findings by coupling genome-wide association study data with …

1Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephens
Green, Dublin 2, Ireland; 2Department of Clinical Pharmacology and Therapeutics, Imperial …

Approaches for gene detection Hypertension is a multifactorial expression of multiple
genetic influences. The genetic polymorphisms that are thought to exist in approximately 2 …