This study investigated alterations in the function and expression of P-glycoprotein (P-GP),
breast cancer resistance protein (BCRP), and multidrug resistance-associated protein 2 …

Abstract Background P‐glycoprotein (P‐GP) and multidrug resistance‐associated protein 2
(MRP 2) are involved in transport of many drugs across blood–brain barrier (BBB). The …

Liver failure is often associated with hepatic encephalopathy, due to dyshomeostasis of the
central nervous system (CNS). Under physiological conditions, the CNS homeostasis is …

We once reported that P‐glycoprotein (P‐GP) and multidrug resistance‐associated protein 2
(MRP 2) were oppositely regulated at the blood–brain barrier (BBB) of thioacetamide …

Aim: Liver failure is associated with dyshomeostasis of efflux transporters at the blood-brain
barrier (BBB), which contributes to hepatic encephalopathy. In this study we examined …

Pathophysiological changes of infection or inflammation are associated with alterations in
the production of numerous absorption, distribution, metabolism and excretion-related …

Purpose The brain is protected from circulating metabolites and xenobiotics by the blood–
brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Previous studies report …

Knockout (KO) animals are useful tools with which to assess the interplay between P-
glycoprotein (P-gp; Abcb1) and the breast cancer resistance protein (Bcrp, Abcg2), two …

Breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp) are co-located at blood–
brain barrier (BBB) cells, preventing their substrates from entering brain. Accumulating …

The role of breast cancer resistance protein (Bcrp) and the combined activities of Bcrp and P-
glycoprotein (P-gp, Mdr1a/1b) in limiting the brain penetration of drugs at the blood-brain …