Metabolic stress, autophagy, and cardiovascular aging: from pathophysiology to therapeutics

J Ren, JR Sowers, Y Zhang - Trends in Endocrinology & Metabolism, 2018 - cell.com
Recent advances in health care have improved the management of cardiometabolic
disorders, and prolonged lifespan. However, the ever-rising prevalence of metabolic stress …

Autophagy in cardiovascular aging

M Abdellatif, S Sedej, D Carmona-Gutierrez… - Circulation …, 2018 - Am Heart Assoc
Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging
promotes the structural and functional declines of both the heart and the blood circulation …

Targeting autophagy in aging and aging-related cardiovascular diseases

J Ren, Y Zhang - Trends in pharmacological sciences, 2018 - cell.com
Aging, an irreversible biological process, serves as an independent risk factor for chronic
disease including cancer, pulmonary, neurodegenerative, and cardiovascular diseases. In …

Hallmarks of cardiovascular ageing

M Abdellatif, PP Rainer, S Sedej… - Nature Reviews …, 2023 - nature.com
Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Staying young at heart: autophagy and adaptation to cardiac aging

LJ Leon, ÅB Gustafsson - Journal of Molecular and Cellular Cardiology, 2016 - Elsevier
Aging is a predominant risk factor for developing cardiovascular disease. Therefore, the
cellular processes that contribute to aging are attractive targets for therapeutic interventions …

[HTML][HTML] Role of autophagy in metabolic syndrome-associated heart disease

SY Ren, X Xu - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2015 - Elsevier
Metabolic syndrome is a constellation of multiple metabolic risk factors including abdominal
obesity, glucose intolerance, insulin resistance, dyslipidemia and hypertension. Over the …

Autophagy as an emerging target in cardiorenal metabolic disease: from pathophysiology to management

Y Zhang, AT Whaley-Connell, JR Sowers… - Pharmacology & …, 2018 - Elsevier
Although advances in medical technology and health care have improved the early
diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity …

Protein and mitochondria quality control mechanisms and cardiac aging

R Ghosh, V Vinod, JD Symons, S Boudina - Cells, 2020 - mdpi.com
Cardiovascular disease (CVD) is the number one cause of death in the United States.
Advancing age is a primary risk factor for developing CVD. Estimates indicate that 20% of …

Autophagy and cardiovascular aging: lesson learned from rapamycin

S Nair, J Ren - Cell cycle, 2012 - Taylor & Francis
The biological aging process is commonly associated with increased risk of cardiovascular
diseases. Several theories have been put forward for aging-associated deterioration in …

The impact of autophagy on cardiovascular senescence and diseases

Y Sasaki, Y Ikeda, M Iwabayashi, Y Akasaki… - International heart …, 2017 - jstage.jst.go.jp
The risk of cardiovascular disease increases with age, causing chronic disability, morbidity,
and mortality in the elderly. Cardiovascular aging and disease are characterized by heart …