It is a common treatment strategy in the clinic to transplant a vascularized bone flap for a
large bone defect. But it is difficult for peripheral blood vessels to grow into the central region …

An experimental model for the prefabrication of a vascularized bone flap was developed in
this study. To form vascularized bone in the desired configuration and to increase the …

The repair of bone defects remains a major clinical challenge because none available
reconstruction methods and biomaterials have been proved completely satisfactory. As a …

This article describes the prefabrication of a vascularized bone graft composed of
autologous particulate cancellous bone and marrow (PCBM), a vessel bundle, and a …

The repair of bone defects poses a great challenge for reconstructive surgeons. Although
the development of tißsue engineering has exhibited promise in replacing damaged bone …

Vascularization is currently considered the biggest challenge in bone tissue engineering
due to necrosis in the center of large scaffolds. We established a new expendable vascular …

The repair of large bone defects with complex geometries remains a major clinical
challenge. Here, we explored the feasibility of fabricating polylactic acid-hydroxyapatite …

Abstract 3D-printed biofunctional scaffolds have promising applications in bone tissue
regeneration. However, the development of bioinks with rapid internal vascularization …

Bioengineered bone substitutes might represent alternatives to autologous bone grafts in
medically compromised patients due to reduced operation time and comorbidity. Due to the …

Natural bone is a highly vascularized tissue that relies on the vasculature for blood and
nutrients supply to maintain skeletal integrity. Inadequacy of neovascularization may …