A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal …

H Ma, X Zhang, W Zeng, J Zhou, X Chi, S Chen… - Cell Discovery, 2022 - nature.com
Abstract Current SARS-CoV-2 Omicron subvariants impose a heavy burden on global health
systems by evading immunity from most developed neutralizing antibodies and vaccines …

[HTML][HTML] A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants

N Modhiran, SM Lauer, AA Amarilla, P Hewins… - Iscience, 2023 - cell.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) Omicron variant sub-
lineages spread rapidly worldwide, mostly due to their immune-evasive properties. This has …

A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration

X Wu, L Cheng, M Fu, B Huang, L Zhu, S Xu, H Shi… - Cell reports, 2021 - cell.com
The dramatically expanding coronavirus disease 2019 (COVID-19) needs multiple effective
countermeasures. Neutralizing nanobodies (Nbs) are a potential therapeutic strategy for …

Development of a bispecific nanobody conjugate broadly neutralizes diverse SARS-CoV-2 variants and structural basis for its broad neutralization

J Yang, S Lin, Z Chen, F Yang, L Guo, L Wang… - PLoS …, 2023 - journals.plos.org
The continuous emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) variants with increased transmissibility and profound immune-escape capacity makes it …

Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA. 1, BA. 2, and BA. 4/5 and diverse sarbecoviruses

M Li, Y Ren, ZQ Aw, B Chen, Z Yang, Y Lei… - Nature …, 2022 - nature.com
Abstract As SARS-CoV-2 Omicron and other variants of concern (VOCs) continue spreading
worldwide, development of antibodies and vaccines to confer broad and protective activity is …

A multivalent and thermostable nanobody neutralizing SARS-CoV-2 omicron (B. 1.1. 529)

Y Lu, Q Li, H Fan, C Liao, J Zhang, H Hu… - International Journal …, 2023 - Taylor & Francis
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron
variants have risen to dominance, which contains far more mutations in the spike protein in …

Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron

H Ma, X Zhang, P Zheng, PH Dube, W Zeng, S Chen… - Cell Research, 2022 - nature.com
SARS-CoV-2 variants with adaptive mutations have continued to emerge, causing fresh
waves of infection even amongst vaccinated population. The development of broad …

Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models

MA Rossotti, H van Faassen, AT Tran, J Sheff… - Communications …, 2022 - nature.com
Nanobodies offer several potential advantages over mAbs for the control of SARS-CoV-2.
Their ability to access cryptic epitopes conserved across SARS-CoV-2 variants of concern …

Combating the SARS-CoV-2 Omicron (BA. 1) and BA. 2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies

Y Wang, X Zhang, Y Ma, Y Wang, W Zhan, Q Zheng… - Cell Discovery, 2022 - nature.com
The highly mutated and transmissible Omicron (BA. 1) and its more contagious lineage BA.
2 have provoked serious concerns over their decreased sensitivity to the current COVID-19 …

[HTML][HTML] Two pan-SARS-CoV-2 nanobodies and their multivalent derivatives effectively prevent Omicron infections in mice

H Liu, L Wu, B Liu, K Xu, W Lei, J Deng, X Rong… - Cell Reports …, 2023 - cell.com
With the widespread vaccinations against coronavirus disease 2019 (COVID-19), we are
witnessing gradually waning neutralizing antibodies and increasing cases of breakthrough …