Simple Summary The cancer associated protein BRCA2 is the subject of intense continual
study. Because of this, new insights into the relation of specific variants of this gene and …

Since the identification of the BRCA1 gene 10 years ago much has been learned about the
role of the BRCA1 protein in cancer development. In particular, genetic and epidemiological …

Background BRCA2 germline mutations are known to predispose carriers to various cancer
types, including breast, ovarian, pancreatic and prostate cancer. An association with …

Over the past decade, genetic testing for rare inherited mutations, such as BRCA1 and
BRCA2 mutations, has been successfully incorporated into clinical practice. Next-generation …

Germ-line mutations in BRCA1 account for the majority of familial breast and ovarian cancer
cases and development of cancer in individuals who carry such mutations requires somatic …

Background: The role of deep intronic variants in hereditary cancer susceptibility has been
largely understudied. Previously, the BRCA2 c. 6937+ 594T> G variant has been shown to …

BRCA1 and BRCA2 are the major genes predisposing to breast–ovarian cancer (ie, breast
or ovarian cancer or both). Since 1994, hundreds of distinct germline alterations have been …

THE IDENTIFICATION OF BRCA1 and BRCA21, 2 marked the first time that highly penetrant
cancer predisposition genes were linked to the development of a common cancer, raising …

Background BRCA1/2 pathogenic variants have become associated with familial breast and
ovarian cancers, and hereditary cancer‐predisposition syndrome. With advances in …

Hereditary breast and ovarian cancer (HBOC) syndrome is a genetic condition that
increases the risk of breast cancer by 80% and that of ovarian cancer by 40%. The most …