Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores

AI Campos, S Namba, SC Lin, K Nam, J Sidorenko… - Nature Genetics, 2023 - nature.com
Genome-wide association studies (GWASs) have been mostly conducted in populations of
European ancestry, which currently limits the transferability of their findings to other …

[HTML][HTML] GWAS Central: a comprehensive resource for the comparison and interrogation of genome-wide association studies

T Beck, RK Hastings, S Gollapudi, RC Free… - European journal of …, 2014 - nature.com
To facilitate broad and convenient integrative visualization of and access to GWAS data, we
have created the GWAS Central resource (http://www. gwascentral. org). This database …

[HTML][HTML] Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study

CS Carlson, TC Matise, KE North, CA Haiman… - PLoS …, 2013 - journals.plos.org
The vast majority of genome-wide association study (GWAS) findings reported to date are
from populations with European Ancestry (EA), and it is not yet clear how broadly the genetic …

Novel method to estimate the phenotypic variation explained by genome‐wide association studies reveals large fraction of the missing heritability

Z Kutalik, J Whittaker, D Waterworth… - Genetic …, 2011 - Wiley Online Library
Genome‐wide association studies (GWAS) are conducted with the promise to discover
novel genetic variants associated with diverse traits. For most traits, associated markers …

[HTML][HTML] Genome-wide association studies

E Uffelmann, QQ Huang, NS Munung… - Nature Reviews …, 2021 - nature.com
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …

[HTML][HTML] An overview of strategies for detecting genotype-phenotype associations across ancestrally diverse populations

I Simonin-Wilmer, P Orozco-del-Pino, DT Bishop… - Frontiers in …, 2021 - frontiersin.org
Genome-wide association studies (GWAS) have been very successful at identifying genetic
variants influencing a large number of traits. Although the great majority of these studies …

[PDF][PDF] Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations

RE Peterson, K Kuchenbaecker, RK Walters, CY Chen… - Cell, 2019 - cell.com
Genome-wide association studies (GWASs) have focused primarily on populations of
European descent, but it is essential that diverse populations become better represented …

An atlas of genetic associations in UK Biobank

O Canela-Xandri, K Rawlik, A Tenesa - Nature genetics, 2018 - nature.com
Genome-wide association studies (GWAS) have identified many loci contributing to variation
in complex traits, yet the majority of loci that contribute to the heritability of complex traits …

[HTML][HTML] Multiethnic genetic association studies improve power for locus discovery

SL Pulit, BF Voight, PIW de Bakker - PloS one, 2010 - journals.plos.org
To date, genome-wide association studies have focused almost exclusively on populations
of European ancestry. These studies continue with the advent of next-generation …

Consistency of genome-wide associations across major ancestral groups

EE Ntzani, G Liberopoulos, TA Manolio, JPA Ioannidis - Human genetics, 2012 - Springer
It is not well known whether genetic markers identified through genome-wide association
studies (GWAS) confer similar or different risks across people of different ancestry. We …